Breast cancer stem cells

Dong Soon Choi; Roberto R. Rosato; Jenny C. Chang

doi:10.1007/978-3-319-41761-5_10

Breast cancer stem cells

Dong Soon Choi, Roberto R. Rosato, Jenny C. Chang

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cancer stem cells (CSCs) represent a heterogeneous subpopulation of cancer cells within tumors. CSCs divide asymmetrically to generate daughter cells that either have CSC characteristics including self-renewal, or differentiation potential to form neoplastic cells which constitute most of the tumor. These characteristics suggest that the cells may play an important role in tumor initiation, and development of chemo-resistance. These characteristics are evident in the ability of CSCs to seed new tumors upon transplantation in experimental animal models. In this chapter, we describe the evidence around the role of CSCs in breast cancer. A brief overview of the methods and markers used to identify these cells is also provided. More importantly, we present the data regarding the signaling pathways that are implicated in the aggressiveness associated with CSCs. Lastly, we discuss the strategies that can be used for targeting these pathways for therapeutic purposes.

Original language	English (US)
Title of host publication	Molecular Pathology of Breast Cancer
Publisher	Springer International Publishing
Pages	133-151
Number of pages	19
ISBN (Electronic)	9783319417615
ISBN (Print)	9783319417592
DOIs	https://doi.org/10.1007/978-3-319-41761-5_10
State	Published - Jan 1 2016

Keywords

ALDH1
CD24
CD44
Chemo-resistance
Cscs

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1007/978-3-319-41761-5_10

Cite this

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abstract = "Cancer stem cells (CSCs) represent a heterogeneous subpopulation of cancer cells within tumors. CSCs divide asymmetrically to generate daughter cells that either have CSC characteristics including self-renewal, or differentiation potential to form neoplastic cells which constitute most of the tumor. These characteristics suggest that the cells may play an important role in tumor initiation, and development of chemo-resistance. These characteristics are evident in the ability of CSCs to seed new tumors upon transplantation in experimental animal models. In this chapter, we describe the evidence around the role of CSCs in breast cancer. A brief overview of the methods and markers used to identify these cells is also provided. More importantly, we present the data regarding the signaling pathways that are implicated in the aggressiveness associated with CSCs. Lastly, we discuss the strategies that can be used for targeting these pathways for therapeutic purposes.",

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N2 - Cancer stem cells (CSCs) represent a heterogeneous subpopulation of cancer cells within tumors. CSCs divide asymmetrically to generate daughter cells that either have CSC characteristics including self-renewal, or differentiation potential to form neoplastic cells which constitute most of the tumor. These characteristics suggest that the cells may play an important role in tumor initiation, and development of chemo-resistance. These characteristics are evident in the ability of CSCs to seed new tumors upon transplantation in experimental animal models. In this chapter, we describe the evidence around the role of CSCs in breast cancer. A brief overview of the methods and markers used to identify these cells is also provided. More importantly, we present the data regarding the signaling pathways that are implicated in the aggressiveness associated with CSCs. Lastly, we discuss the strategies that can be used for targeting these pathways for therapeutic purposes.

AB - Cancer stem cells (CSCs) represent a heterogeneous subpopulation of cancer cells within tumors. CSCs divide asymmetrically to generate daughter cells that either have CSC characteristics including self-renewal, or differentiation potential to form neoplastic cells which constitute most of the tumor. These characteristics suggest that the cells may play an important role in tumor initiation, and development of chemo-resistance. These characteristics are evident in the ability of CSCs to seed new tumors upon transplantation in experimental animal models. In this chapter, we describe the evidence around the role of CSCs in breast cancer. A brief overview of the methods and markers used to identify these cells is also provided. More importantly, we present the data regarding the signaling pathways that are implicated in the aggressiveness associated with CSCs. Lastly, we discuss the strategies that can be used for targeting these pathways for therapeutic purposes.

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Breast cancer stem cells

Abstract

Keywords

ASJC Scopus subject areas

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