TY - JOUR
T1 - C. elegans for anti-infective discovery
AU - Arvanitis, Marios
AU - Glavis-Bloom, Justin
AU - Mylonakis, Eleftherios
PY - 2013/10
Y1 - 2013/10
N2 - Widespread use of antimicrobial agents has led to the emergence of multidrug resistant pathogens, which are becoming increasingly common in clinical practice. This underscores the need to discover novel anti-infective compounds. The soil-living nematode Caenorhabditis elegans has proved to be an excellent model host in the search for such compounds. Indeed, this alternative host is successfully being used to identify traditional microbicidal agents, including antihelminthic compounds, as well as novel agents that attenuate microbial virulence or enhance the host's immune response. Thanks to numerous advantageous features, including its amenability to high-throughput automated screens that allow for the detection of bioactive products among thousands of tested substances, the C. elegans model is now in the spotlight of scientific attention.
AB - Widespread use of antimicrobial agents has led to the emergence of multidrug resistant pathogens, which are becoming increasingly common in clinical practice. This underscores the need to discover novel anti-infective compounds. The soil-living nematode Caenorhabditis elegans has proved to be an excellent model host in the search for such compounds. Indeed, this alternative host is successfully being used to identify traditional microbicidal agents, including antihelminthic compounds, as well as novel agents that attenuate microbial virulence or enhance the host's immune response. Thanks to numerous advantageous features, including its amenability to high-throughput automated screens that allow for the detection of bioactive products among thousands of tested substances, the C. elegans model is now in the spotlight of scientific attention.
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U2 - 10.1016/j.coph.2013.08.002
DO - 10.1016/j.coph.2013.08.002
M3 - Review article
C2 - 23993686
AN - SCOPUS:84892967261
SN - 1471-4892
VL - 13
SP - 769
EP - 774
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 5
ER -