Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation

Sara Rogers; Patrick J. Silva; George Udeani; Monica Deleon; Sriarchala Mutyala; Ladan Panahi; Asim Abu-Baker; Gabriel Neal; Kenneth S. Ramos

doi:10.1007/s40268-023-00451-5

Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation

Sara Rogers, Patrick J. Silva, George Udeani, Monica Deleon, Sriarchala Mutyala, Ladan Panahi, Asim Abu-Baker, Gabriel Neal, Kenneth S. Ramos

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Selective serotonin reuptake inhibitors (SSRI) are commonly used for the treatment of depression and anxiety. Inhibition of serotonin reuptake in platelets increases bleeding risk in patients taking SSRIs. Case: Here, we present the case of a 52-year-old patient who developed severe postsurgical bleeding requiring blood transfusion following panniculectomy. Conclusion: SSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters. Video abstract: BJYwPVEYn-uvqVov7uRYgK Supplementary file1 (MP4 8441 KB).

Original language	English (US)
Journal	Drugs in R and D
DOIs	https://doi.org/10.1007/s40268-023-00451-5
State	Accepted/In press - 2024

ASJC Scopus subject areas

Pharmacology

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10.1007/s40268-023-00451-5

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title = "Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation",

abstract = "Background: Selective serotonin reuptake inhibitors (SSRI) are commonly used for the treatment of depression and anxiety. Inhibition of serotonin reuptake in platelets increases bleeding risk in patients taking SSRIs. Case: Here, we present the case of a 52-year-old patient who developed severe postsurgical bleeding requiring blood transfusion following panniculectomy. Conclusion: SSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters. Video abstract: BJYwPVEYn-uvqVov7uRYgK Supplementary file1 (MP4 8441 KB).",

author = "Sara Rogers and Silva, {Patrick J.} and George Udeani and Monica Deleon and Sriarchala Mutyala and Ladan Panahi and Asim Abu-Baker and Gabriel Neal and Ramos, {Kenneth S.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

doi = "10.1007/s40268-023-00451-5",

language = "English (US)",

journal = "Drugs in R and D",

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TY - JOUR

T1 - Case Report

T2 - Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation

AU - Rogers, Sara

AU - Silva, Patrick J.

AU - Udeani, George

AU - Deleon, Monica

AU - Mutyala, Sriarchala

AU - Panahi, Ladan

AU - Abu-Baker, Asim

AU - Neal, Gabriel

AU - Ramos, Kenneth S.

PY - 2024

Y1 - 2024

N2 - Background: Selective serotonin reuptake inhibitors (SSRI) are commonly used for the treatment of depression and anxiety. Inhibition of serotonin reuptake in platelets increases bleeding risk in patients taking SSRIs. Case: Here, we present the case of a 52-year-old patient who developed severe postsurgical bleeding requiring blood transfusion following panniculectomy. Conclusion: SSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters. Video abstract: BJYwPVEYn-uvqVov7uRYgK Supplementary file1 (MP4 8441 KB).

AB - Background: Selective serotonin reuptake inhibitors (SSRI) are commonly used for the treatment of depression and anxiety. Inhibition of serotonin reuptake in platelets increases bleeding risk in patients taking SSRIs. Case: Here, we present the case of a 52-year-old patient who developed severe postsurgical bleeding requiring blood transfusion following panniculectomy. Conclusion: SSRI-induced bleeding is dose-related and strongly influenced by individual variations in drug metabolizing enzymes and transporters. Video abstract: BJYwPVEYn-uvqVov7uRYgK Supplementary file1 (MP4 8441 KB).

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JO - Drugs in R and D

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ER -

Case Report: Life-Threatening Fluoxetine-Linked Postoperative Bleeding Informed by Pharmacogenetic Evaluation

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