Abstract
The ability of nanoparticles to evade the immune system, cross biological barriers, and localize at the target tissue ultimately determines their therapeutic potential. Leukocytes naturally encompass all of these features and, therefore, provide great inspiration in biomimetic vectors. Herein, we present a hybrid drug delivery system, termed leukolike vectors, composed of a synthetic nanoporous silicon core cloaked with cellular membranes derived from circulating white blood cells. These particles possess the ability to avoid clearance by the mononuclear phagocyte system, interact with endothelial cells through receptor-ligand interaction, and effi ciently deliver a therapeutic payload to infl amed endothelia. Furthermore, in vivo studies revealed an ability to retain the leukocyte membrane's biological function following systemic administration, demonstrating prolonged circulation and improved tumor targeting abilities.
Original language | English (US) |
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Title of host publication | Handbook of Immunological Properties of Engineered Nanomaterials |
Subtitle of host publication | Engineered Nanomaterials and the Immune Cell Function |
Editors | Marina A Dobrovolskaia, Scott E McNeil |
Publisher | World Scientific Publishing Co. Pte Ltd |
Pages | 43-68 |
Number of pages | 26 |
Volume | 3 |
Edition | 2nd |
ISBN (Electronic) | 978-981-4699-18-1 |
ISBN (Print) | 978-981-4699-16-7 |
DOIs | |
State | Published - Apr 1 2016 |
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
- Engineering(all)