Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle

Francisco Altamirano; Jóse M. Eltit; Gaëlle Robin; Nancy Linares; Xudong Ding; Isaac N. Pessah; Paul D. Allen; José R. López

doi:10.1074/jbc.M114.550764

Ca²⁺ influx via the Na⁺/Ca²+ exchanger is enhanced in malignant hyperthermia skeletal muscle

Francisco Altamirano, Jóse M. Eltit, Gaëlle Robin, Nancy Linares, Xudong Ding, Isaac N. Pessah, Paul D. Allen, José R. López

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Background: Dysregulation of Ca²⁺ homeostasis have been described in malignant hyperthermia (MH). Results: Na⁺/Ca ²+ exchanger (NCX3) reverse mode activity is enhanced in MH muscles and it contributes to resting intracellular calcium concentration and Ca ²⁺ transients induced by high [K⁺]e and by halothane. Conclusion: NCX3 reverse mode activity is increased in MH muscle. Significance: Understanding mechanisms influencing Ca²⁺ dynamics in MH muscle.

Original language	English (US)
Pages (from-to)	19180-19190
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	27
DOIs	https://doi.org/10.1074/jbc.M114.550764
State	Published - Jul 4 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle",

abstract = "Background: Dysregulation of Ca2+ homeostasis have been described in malignant hyperthermia (MH). Results: Na+/Ca 2+ exchanger (NCX3) reverse mode activity is enhanced in MH muscles and it contributes to resting intracellular calcium concentration and Ca 2+ transients induced by high [K+]e and by halothane. Conclusion: NCX3 reverse mode activity is increased in MH muscle. Significance: Understanding mechanisms influencing Ca2+ dynamics in MH muscle.",

author = "Francisco Altamirano and Eltit, {J{\'o}se M.} and Ga{\"e}lle Robin and Nancy Linares and Xudong Ding and Pessah, {Isaac N.} and Allen, {Paul D.} and L{\'o}pez, {Jos{\'e} R.}",

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doi = "10.1074/jbc.M114.550764",

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T1 - Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle

AU - Altamirano, Francisco

AU - Eltit, Jóse M.

AU - Robin, Gaëlle

AU - Linares, Nancy

AU - Ding, Xudong

AU - Pessah, Isaac N.

AU - Allen, Paul D.

AU - López, José R.

PY - 2014/7/4

Y1 - 2014/7/4

N2 - Background: Dysregulation of Ca2+ homeostasis have been described in malignant hyperthermia (MH). Results: Na+/Ca 2+ exchanger (NCX3) reverse mode activity is enhanced in MH muscles and it contributes to resting intracellular calcium concentration and Ca 2+ transients induced by high [K+]e and by halothane. Conclusion: NCX3 reverse mode activity is increased in MH muscle. Significance: Understanding mechanisms influencing Ca2+ dynamics in MH muscle.

AB - Background: Dysregulation of Ca2+ homeostasis have been described in malignant hyperthermia (MH). Results: Na+/Ca 2+ exchanger (NCX3) reverse mode activity is enhanced in MH muscles and it contributes to resting intracellular calcium concentration and Ca 2+ transients induced by high [K+]e and by halothane. Conclusion: NCX3 reverse mode activity is increased in MH muscle. Significance: Understanding mechanisms influencing Ca2+ dynamics in MH muscle.

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 27

ER -

Ca²⁺ influx via the Na⁺/Ca²+ exchanger is enhanced in malignant hyperthermia skeletal muscle

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