Cefazolin and ertapenem salvage therapy rapidly clears persistent methicillin-susceptible staphylococcus aureus bacteremia

Erlinda R. Ulloa; Kavindra V. Singh; Matthew Geriak; Fadi Haddad; Barbara E. Murray; Victor Nizet; George Sakoulas

doi:10.1093/cid/ciz995

Cefazolin and ertapenem salvage therapy rapidly clears persistent methicillin-susceptible staphylococcus aureus bacteremia

Erlinda R. Ulloa, Kavindra V. Singh, Matthew Geriak, Fadi Haddad, Barbara E. Murray, Victor Nizet, George Sakoulas

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis. The combination of cefazolin and ertapenem provides potent in vivo activity against MSSA beyond what is predicted in vitro and warrants further clinical study in the treatment of refractory MSSA bacteremia and endocarditis.

Original language	English (US)
Pages (from-to)	1413-1418
Number of pages	6
Journal	Clinical Infectious Diseases
Volume	71
Issue number	6
DOIs	https://doi.org/10.1093/cid/ciz995
State	Published - Sep 15 2020

Keywords

Bacteremia
Cefazolin
Endocarditis
Ertapenem
Staphylococcus aureus

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciz995

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abstract = "Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis. The combination of cefazolin and ertapenem provides potent in vivo activity against MSSA beyond what is predicted in vitro and warrants further clinical study in the treatment of refractory MSSA bacteremia and endocarditis.",

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AU - Ulloa, Erlinda R.

AU - Singh, Kavindra V.

AU - Geriak, Matthew

AU - Haddad, Fadi

AU - Murray, Barbara E.

AU - Nizet, Victor

AU - Sakoulas, George

PY - 2020/9/15

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AB - Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis. The combination of cefazolin and ertapenem provides potent in vivo activity against MSSA beyond what is predicted in vitro and warrants further clinical study in the treatment of refractory MSSA bacteremia and endocarditis.

KW - Bacteremia

KW - Cefazolin

KW - Endocarditis

KW - Ertapenem

KW - Staphylococcus aureus

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Cefazolin and ertapenem salvage therapy rapidly clears persistent methicillin-susceptible staphylococcus aureus bacteremia

Abstract

Keywords

ASJC Scopus subject areas

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