@article{8a38ff20942a4b81a608fd6957b8141c,
title = "Cefazolin and ertapenem salvage therapy rapidly clears persistent methicillin-susceptible staphylococcus aureus bacteremia",
abstract = "Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis. The combination of cefazolin and ertapenem provides potent in vivo activity against MSSA beyond what is predicted in vitro and warrants further clinical study in the treatment of refractory MSSA bacteremia and endocarditis.",
keywords = "Bacteremia, Cefazolin, Endocarditis, Ertapenem, Staphylococcus aureus",
author = "Ulloa, {Erlinda R.} and Singh, {Kavindra V.} and Matthew Geriak and Fadi Haddad and Murray, {Barbara E.} and Victor Nizet and George Sakoulas",
note = "Funding Information: This research was supported by the National Institutes of Health: the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD; Pediatric Scientist Development Program Fellowship K12-HD000850 to E. R. U.) and the National Institute of Allergy and Infectious Diseases (grant numbers U01-AI124316-01 and U54-HD090259 to V. N. and G. S.). Publisher Copyright: {\textcopyright} The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.",
year = "2020",
month = sep,
day = "15",
doi = "10.1093/cid/ciz995",
language = "English (US)",
volume = "71",
pages = "1413--1418",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "6",
}