Cell biology of tubotympanum in relation to pathogenesis of otitis media - A review

D. J. Lim; Y. M. Chun; H. Y. Lee; S. K. Moon; K. H. Chang; J. D. Li; A. Andalibi

doi:10.1016/S0264-410X(00)00273-5

Cell biology of tubotympanum in relation to pathogenesis of otitis media - A review

D. J. Lim, Y. M. Chun, H. Y. Lee, S. K. Moon, K. H. Chang, J. D. Li, A. Andalibi

Research output: Contribution to journal › Short survey › peer-review

97 Scopus citations

Abstract

The sterility of the eustachian tube and tympanic cavity of normal individuals is maintained not only by the adaptive immune system, but also by the mucociliary system and the antimicrobial molecules of innate immunity. Mucin production and periciliary fluid homeostasis are essential for normal mucociliary function and dysfunction of this system is an important risk factor for otitis media. The secreted antimicrobial molecules of the tubotympanum include lysozyme, lactoferrin, beta defensins, and the surfactant proteins A and D (SP-A, SP-D). Defects in the expression or regulation of these molecules may also be the major risk factor for otitis media.

Original language	English (US)
Pages (from-to)	S17-S25
Journal	Vaccine
Volume	19
DOIs	https://doi.org/10.1016/S0264-410X(00)00273-5
State	Published - Dec 8 2000

Keywords

Innate immunity
Otitis media pathogenesis
Tubotympanum

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/S0264-410X(00)00273-5

Cite this

@article{54e7445609a144849fa5d68e6c2fc4d8,

title = "Cell biology of tubotympanum in relation to pathogenesis of otitis media - A review",

abstract = "The sterility of the eustachian tube and tympanic cavity of normal individuals is maintained not only by the adaptive immune system, but also by the mucociliary system and the antimicrobial molecules of innate immunity. Mucin production and periciliary fluid homeostasis are essential for normal mucociliary function and dysfunction of this system is an important risk factor for otitis media. The secreted antimicrobial molecules of the tubotympanum include lysozyme, lactoferrin, beta defensins, and the surfactant proteins A and D (SP-A, SP-D). Defects in the expression or regulation of these molecules may also be the major risk factor for otitis media.",

keywords = "Innate immunity, Otitis media pathogenesis, Tubotympanum",

author = "Lim, {D. J.} and Chun, {Y. M.} and Lee, {H. Y.} and Moon, {S. K.} and Chang, {K. H.} and Li, {J. D.} and A. Andalibi",

year = "2000",

month = dec,

day = "8",

doi = "10.1016/S0264-410X(00)00273-5",

language = "English (US)",

volume = "19",

pages = "S17--S25",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Cell biology of tubotympanum in relation to pathogenesis of otitis media - A review

AU - Lim, D. J.

AU - Chun, Y. M.

AU - Lee, H. Y.

AU - Moon, S. K.

AU - Chang, K. H.

AU - Li, J. D.

AU - Andalibi, A.

PY - 2000/12/8

Y1 - 2000/12/8

N2 - The sterility of the eustachian tube and tympanic cavity of normal individuals is maintained not only by the adaptive immune system, but also by the mucociliary system and the antimicrobial molecules of innate immunity. Mucin production and periciliary fluid homeostasis are essential for normal mucociliary function and dysfunction of this system is an important risk factor for otitis media. The secreted antimicrobial molecules of the tubotympanum include lysozyme, lactoferrin, beta defensins, and the surfactant proteins A and D (SP-A, SP-D). Defects in the expression or regulation of these molecules may also be the major risk factor for otitis media.

AB - The sterility of the eustachian tube and tympanic cavity of normal individuals is maintained not only by the adaptive immune system, but also by the mucociliary system and the antimicrobial molecules of innate immunity. Mucin production and periciliary fluid homeostasis are essential for normal mucociliary function and dysfunction of this system is an important risk factor for otitis media. The secreted antimicrobial molecules of the tubotympanum include lysozyme, lactoferrin, beta defensins, and the surfactant proteins A and D (SP-A, SP-D). Defects in the expression or regulation of these molecules may also be the major risk factor for otitis media.

KW - Innate immunity

KW - Otitis media pathogenesis

KW - Tubotympanum

UR - http://www.scopus.com/inward/record.url?scp=0034623903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034623903&partnerID=8YFLogxK

U2 - 10.1016/S0264-410X(00)00273-5

DO - 10.1016/S0264-410X(00)00273-5

M3 - Short survey

C2 - 11163458

AN - SCOPUS:0034623903

SN - 0264-410X

VL - 19

SP - S17-S25

JO - Vaccine

JF - Vaccine

ER -

Cell biology of tubotympanum in relation to pathogenesis of otitis media - A review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this