TY - JOUR
T1 - Cell type-specific function of TAK1 in innate immune signaling
AU - Ajibade, Adebusola A.
AU - Wang, Helen Y.
AU - Wang, Rong Fu
N1 - Funding Information:
This work was in part supported by grants from the National Cancer Institute, National Institutes of Health (NIH; R01CA090327, R01CA101795, R01CA116408, R01CA121191, and R01DA030338), the Cancer Prevention and Research Institute of Texas (RP121048) to R-F.W., and the Methodist Hospital Research Institute.
PY - 2013/7
Y1 - 2013/7
N2 - Transforming growth factor β-activated kinase 1 (TAK1 or MAP3K7) is a key signaling component of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Activation of TAK1 is tightly regulated through its binding partners and protein modifications. Although TAK1 functions as an essential and positive regulator of innate immune signaling and apoptosis in mouse embryonic fibroblasts (MEFs), T cells, and other cells, it negatively regulates cell development and activation of proinflammatory signaling pathways in neutrophils. However, the molecular mechanisms responsible for the opposite roles of TAK1 in different cell types remain to be addressed. In this article, we discuss the latest progresses in our understanding of TAK1 regulation, function, and mechanisms in a cell-type specific manner.
AB - Transforming growth factor β-activated kinase 1 (TAK1 or MAP3K7) is a key signaling component of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Activation of TAK1 is tightly regulated through its binding partners and protein modifications. Although TAK1 functions as an essential and positive regulator of innate immune signaling and apoptosis in mouse embryonic fibroblasts (MEFs), T cells, and other cells, it negatively regulates cell development and activation of proinflammatory signaling pathways in neutrophils. However, the molecular mechanisms responsible for the opposite roles of TAK1 in different cell types remain to be addressed. In this article, we discuss the latest progresses in our understanding of TAK1 regulation, function, and mechanisms in a cell-type specific manner.
KW - innate immune signaling
KW - NF-κB pathway
KW - reactive oxygen species
KW - TAK1 complex
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U2 - 10.1016/j.it.2013.03.007
DO - 10.1016/j.it.2013.03.007
M3 - Review article
C2 - 23664135
AN - SCOPUS:84880847105
SN - 1471-4906
VL - 34
SP - 307
EP - 316
JO - Trends in Immunology
JF - Trends in Immunology
IS - 7
ER -