Central control of lactogenic receptors in liver membranes: Effect of hypothalamic deafferentation

Gunnar Norstedt; Peter Eneroth; Jan Åke Gustafsson; Tomas Hökfelt; Paul Skett

doi:10.1016/0303-7207(79)90026-1

Central control of lactogenic receptors in liver membranes: Effect of hypothalamic deafferentation

Gunnar Norstedt, Peter Eneroth, Jan Åke Gustafsson, Tomas Hökfelt, Paul Skett

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The regulation by the central nervous system of a lactogenic receptor, present in the rat liver, was studied. The receptor, which is present in very low concentration or absent in the male rat, can be induced by anterior hypothalamic deafferentation, resulting in a typically female level of the receptor in lesioned male animals. Our observations indicate an important role of the brain in regulation of peripheral lactogenic receptors.

Original language	English (US)
Pages (from-to)	199-204
Number of pages	6
Journal	Molecular and cellular endocrinology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/0303-7207(79)90026-1
State	Published - Dec 1979

Keywords

hypothalamus
prolactin receptor
sex difference

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/0303-7207(79)90026-1

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title = "Central control of lactogenic receptors in liver membranes: Effect of hypothalamic deafferentation",

abstract = "The regulation by the central nervous system of a lactogenic receptor, present in the rat liver, was studied. The receptor, which is present in very low concentration or absent in the male rat, can be induced by anterior hypothalamic deafferentation, resulting in a typically female level of the receptor in lesioned male animals. Our observations indicate an important role of the brain in regulation of peripheral lactogenic receptors.",

keywords = "hypothalamus, prolactin receptor, sex difference",

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year = "1979",

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T2 - Effect of hypothalamic deafferentation

AU - Norstedt, Gunnar

AU - Eneroth, Peter

AU - Gustafsson, Jan Åke

AU - Hökfelt, Tomas

AU - Skett, Paul

PY - 1979/12

Y1 - 1979/12

N2 - The regulation by the central nervous system of a lactogenic receptor, present in the rat liver, was studied. The receptor, which is present in very low concentration or absent in the male rat, can be induced by anterior hypothalamic deafferentation, resulting in a typically female level of the receptor in lesioned male animals. Our observations indicate an important role of the brain in regulation of peripheral lactogenic receptors.

AB - The regulation by the central nervous system of a lactogenic receptor, present in the rat liver, was studied. The receptor, which is present in very low concentration or absent in the male rat, can be induced by anterior hypothalamic deafferentation, resulting in a typically female level of the receptor in lesioned male animals. Our observations indicate an important role of the brain in regulation of peripheral lactogenic receptors.

KW - hypothalamus

KW - prolactin receptor

KW - sex difference

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ER -

Central control of lactogenic receptors in liver membranes: Effect of hypothalamic deafferentation

Abstract

Keywords

ASJC Scopus subject areas

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