Characteristic of hypothalamic kisspeptin expression in the pubertal development of precocious female rats

Yan Sun; Zhanzhuang Tian; Hong Zhao; Stephen T.C. Wong; Boying Chen

doi:10.1016/j.neulet.2007.04.003

Characteristic of hypothalamic kisspeptin expression in the pubertal development of precocious female rats

Yan Sun, Zhanzhuang Tian, Hong Zhao, Stephen T.C. Wong, Boying Chen

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

To investigate the potential role of kisspeptin in the advance onset of puberty in precocious puberty, model rats induced by danazol were used to study the developmental expression of hypothalamic kisspeptin. Kisspeptin immunoreactive cells were observed in the arcuate nucleus (ARC), periventricular nucleus (PeN) and preoptic area (POA) in model rats on the day of onset-puberty. On the day of post-puberty, however, the number of kisspeptin immunoreactive cells in ARC and PeN decreased while the number of those cells in POA increased. Kisspeptin immunoreactive cells were not detected in hypothalamus in both normal and model rats at their pre-puberty stages. Furthermore, the expression of hypothalamic Kiss-1 mRNA reached top on the day of onset-puberty in both of the normal and model rats, and the expression of Kiss-1 mRNA increased significantly in the model rats compared with those in the normal ones. Our results indicated that kisspeptin might involve in the advance onset of puberty in danazol induced female precocious model rats.

Original language	English (US)
Pages (from-to)	12-17
Number of pages	6
Journal	Neuroscience Letters
Volume	420
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2007.04.003
State	Published - Jun 8 2007

Keywords

Danazol
Gonadotropin releasing hormone
Kisspeptin
Precocious puberty
Rat

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2007.04.003

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@article{ef9cd3fd452845c8a87a82051b740748,

title = "Characteristic of hypothalamic kisspeptin expression in the pubertal development of precocious female rats",

abstract = "To investigate the potential role of kisspeptin in the advance onset of puberty in precocious puberty, model rats induced by danazol were used to study the developmental expression of hypothalamic kisspeptin. Kisspeptin immunoreactive cells were observed in the arcuate nucleus (ARC), periventricular nucleus (PeN) and preoptic area (POA) in model rats on the day of onset-puberty. On the day of post-puberty, however, the number of kisspeptin immunoreactive cells in ARC and PeN decreased while the number of those cells in POA increased. Kisspeptin immunoreactive cells were not detected in hypothalamus in both normal and model rats at their pre-puberty stages. Furthermore, the expression of hypothalamic Kiss-1 mRNA reached top on the day of onset-puberty in both of the normal and model rats, and the expression of Kiss-1 mRNA increased significantly in the model rats compared with those in the normal ones. Our results indicated that kisspeptin might involve in the advance onset of puberty in danazol induced female precocious model rats.",

keywords = "Danazol, Gonadotropin releasing hormone, Kisspeptin, Precocious puberty, Rat",

author = "Yan Sun and Zhanzhuang Tian and Hong Zhao and Wong, {Stephen T.C.} and Boying Chen",

note = "Funding Information: This research was supported by the Younger Scientific Fund of Fudan University (2004), the Younger Start up Fund of Shanghai Medical College (2004), the Century Star Fund (2006).",

year = "2007",

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doi = "10.1016/j.neulet.2007.04.003",

language = "English (US)",

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AU - Sun, Yan

AU - Tian, Zhanzhuang

AU - Zhao, Hong

AU - Wong, Stephen T.C.

AU - Chen, Boying

N1 - Funding Information: This research was supported by the Younger Scientific Fund of Fudan University (2004), the Younger Start up Fund of Shanghai Medical College (2004), the Century Star Fund (2006).

PY - 2007/6/8

Y1 - 2007/6/8

N2 - To investigate the potential role of kisspeptin in the advance onset of puberty in precocious puberty, model rats induced by danazol were used to study the developmental expression of hypothalamic kisspeptin. Kisspeptin immunoreactive cells were observed in the arcuate nucleus (ARC), periventricular nucleus (PeN) and preoptic area (POA) in model rats on the day of onset-puberty. On the day of post-puberty, however, the number of kisspeptin immunoreactive cells in ARC and PeN decreased while the number of those cells in POA increased. Kisspeptin immunoreactive cells were not detected in hypothalamus in both normal and model rats at their pre-puberty stages. Furthermore, the expression of hypothalamic Kiss-1 mRNA reached top on the day of onset-puberty in both of the normal and model rats, and the expression of Kiss-1 mRNA increased significantly in the model rats compared with those in the normal ones. Our results indicated that kisspeptin might involve in the advance onset of puberty in danazol induced female precocious model rats.

AB - To investigate the potential role of kisspeptin in the advance onset of puberty in precocious puberty, model rats induced by danazol were used to study the developmental expression of hypothalamic kisspeptin. Kisspeptin immunoreactive cells were observed in the arcuate nucleus (ARC), periventricular nucleus (PeN) and preoptic area (POA) in model rats on the day of onset-puberty. On the day of post-puberty, however, the number of kisspeptin immunoreactive cells in ARC and PeN decreased while the number of those cells in POA increased. Kisspeptin immunoreactive cells were not detected in hypothalamus in both normal and model rats at their pre-puberty stages. Furthermore, the expression of hypothalamic Kiss-1 mRNA reached top on the day of onset-puberty in both of the normal and model rats, and the expression of Kiss-1 mRNA increased significantly in the model rats compared with those in the normal ones. Our results indicated that kisspeptin might involve in the advance onset of puberty in danazol induced female precocious model rats.

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KW - Precocious puberty

KW - Rat

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Characteristic of hypothalamic kisspeptin expression in the pubertal development of precocious female rats

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