Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

Zongxing Wang; Hung Jen Wu; Daniel Fine; Jeffrey Schmulen; Ye Hu; Biana Godin; John X.J. Zhang; Xuewu Liu

doi:10.1039/c3lc41343h

Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

Zongxing Wang, Hung Jen Wu, Daniel Fine, Jeffrey Schmulen, Ye Hu, Biana Godin, John X.J. Zhang, Xuewu Liu

Research output: Contribution to journal › Article › peer-review

288 Scopus citations

Abstract

We fabricated a microfluidic device consisting of ciliated micropillars, forming a porous silicon nanowire-on-micropillar structure. We demonstrated that the prototype device can preferentially trap exosome-like lipid vesicles, while simultaneously filtering out proteins and cell debris. Trapped lipid vesicles can be recovered intact by dissolving the porous nanowires in PBS buffer.

Original language	English (US)
Pages (from-to)	2879-2882
Number of pages	4
Journal	Lab on a Chip
Volume	13
Issue number	15
DOIs	https://doi.org/10.1039/c3lc41343h
State	Published - Aug 7 2013

ASJC Scopus subject areas

Bioengineering
Biochemistry
Chemistry(all)
Biomedical Engineering

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title = "Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles",

abstract = "We fabricated a microfluidic device consisting of ciliated micropillars, forming a porous silicon nanowire-on-micropillar structure. We demonstrated that the prototype device can preferentially trap exosome-like lipid vesicles, while simultaneously filtering out proteins and cell debris. Trapped lipid vesicles can be recovered intact by dissolving the porous nanowires in PBS buffer.",

author = "Zongxing Wang and Wu, {Hung Jen} and Daniel Fine and Jeffrey Schmulen and Ye Hu and Biana Godin and Zhang, {John X.J.} and Xuewu Liu",

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AU - Wang, Zongxing

AU - Wu, Hung Jen

AU - Fine, Daniel

AU - Schmulen, Jeffrey

AU - Hu, Ye

AU - Godin, Biana

AU - Zhang, John X.J.

AU - Liu, Xuewu

PY - 2013/8/7

Y1 - 2013/8/7

N2 - We fabricated a microfluidic device consisting of ciliated micropillars, forming a porous silicon nanowire-on-micropillar structure. We demonstrated that the prototype device can preferentially trap exosome-like lipid vesicles, while simultaneously filtering out proteins and cell debris. Trapped lipid vesicles can be recovered intact by dissolving the porous nanowires in PBS buffer.

AB - We fabricated a microfluidic device consisting of ciliated micropillars, forming a porous silicon nanowire-on-micropillar structure. We demonstrated that the prototype device can preferentially trap exosome-like lipid vesicles, while simultaneously filtering out proteins and cell debris. Trapped lipid vesicles can be recovered intact by dissolving the porous nanowires in PBS buffer.

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DO - 10.1039/c3lc41343h

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Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

Abstract

ASJC Scopus subject areas

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