Circadian variations of stellate ganglion nerve activity in ambulatory dogs

Byung Chun Jung; Amish S. Dave; Alex Y. Tan; Ghassan Gholmieh; Shengmei Zhou; David C. Wang; A. George Akingba; Gregory A. Fishbein; Carlo Montemagno; Shien Fong Lin; Lan S. Chen; Peng Sheng Chen

doi:10.1016/j.hrthm.2005.09.016

Circadian variations of stellate ganglion nerve activity in ambulatory dogs

Byung Chun Jung, Amish S. Dave, Alex Y. Tan, Ghassan Gholmieh, Shengmei Zhou, David C. Wang, A. George Akingba, Gregory A. Fishbein, Carlo Montemagno, Shien Fong Lin, Lan S. Chen, Peng Sheng Chen

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Background: The presence of circadian variations in sympathetic outflow from the stellate ganglia is unclear. Objectives: The purpose of this study was to continuously record stellate ganglion nerve activity (SGNA) in ambulatory dogs. Methods We performed continuous 24-hour left (N = 3) or bilateral (N = 3) SGNA recordings in normal ambulatory dogs using implanted Data Sciences International transmitters. We also performed simultaneous ECG recording (n = 5) or simultaneous ECG and blood pressure recordings (n = 1). Results: The total duration of continuous ambulatory recording averaged 41.5 ± 16.6 days. Five dogs had persistent stable recording, and one dog developed hardware malfunction in week 3. SGNA was followed immediately (<1 second) by heart rate and blood pressure elevation and a reduced standard deviation of consecutive activation cycle length (SDNN) from 236 ± 93 ms to 121 ± 51 ms (P = 0.007). Heart rate correlated significantly with SGNA. When there was a sudden increase of SGNA, the sudden increase occurred bilaterally in 90% of the episodes. Both heart rate and SGNA showed statistically significant (P <.01) circadian variation. Nadolol (20 mg/day for 5 days) reduced average heart rate from 99 ± 8 bpm at baseline to 88 ± 9 bpm (N = 6, P = .001) but did not significantly alter SGNA. Immunohistochemical staining of the stellate ganglia showed tyrosine hydroxylase-positive ganglion cells and nerves at the recording site. Conclusion: There is a circadian variation in sympathetic outflow from canine stellate ganglia. Circadian variation of SGNA is an important cause of circadian variations of cardiac sympathetic tone.

Original language	English (US)
Pages (from-to)	78-85
Number of pages	8
Journal	Heart Rhythm
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.hrthm.2005.09.016
State	Published - Jan 2006

Keywords

Arrhythmia
Cardiac electrophysiology
Sympathetic nerve activity

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.hrthm.2005.09.016

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@article{058f7c39ac9d48cfa99f8b801a9e36f1,

title = "Circadian variations of stellate ganglion nerve activity in ambulatory dogs",

abstract = "Background: The presence of circadian variations in sympathetic outflow from the stellate ganglia is unclear. Objectives: The purpose of this study was to continuously record stellate ganglion nerve activity (SGNA) in ambulatory dogs. Methods We performed continuous 24-hour left (N = 3) or bilateral (N = 3) SGNA recordings in normal ambulatory dogs using implanted Data Sciences International transmitters. We also performed simultaneous ECG recording (n = 5) or simultaneous ECG and blood pressure recordings (n = 1). Results: The total duration of continuous ambulatory recording averaged 41.5 ± 16.6 days. Five dogs had persistent stable recording, and one dog developed hardware malfunction in week 3. SGNA was followed immediately (<1 second) by heart rate and blood pressure elevation and a reduced standard deviation of consecutive activation cycle length (SDNN) from 236 ± 93 ms to 121 ± 51 ms (P = 0.007). Heart rate correlated significantly with SGNA. When there was a sudden increase of SGNA, the sudden increase occurred bilaterally in 90% of the episodes. Both heart rate and SGNA showed statistically significant (P <.01) circadian variation. Nadolol (20 mg/day for 5 days) reduced average heart rate from 99 ± 8 bpm at baseline to 88 ± 9 bpm (N = 6, P = .001) but did not significantly alter SGNA. Immunohistochemical staining of the stellate ganglia showed tyrosine hydroxylase-positive ganglion cells and nerves at the recording site. Conclusion: There is a circadian variation in sympathetic outflow from canine stellate ganglia. Circadian variation of SGNA is an important cause of circadian variations of cardiac sympathetic tone.",

keywords = "Arrhythmia, Cardiac electrophysiology, Sympathetic nerve activity",

author = "Jung, {Byung Chun} and Dave, {Amish S.} and Tan, {Alex Y.} and Ghassan Gholmieh and Shengmei Zhou and Wang, {David C.} and Akingba, {A. George} and Fishbein, {Gregory A.} and Carlo Montemagno and Lin, {Shien Fong} and Chen, {Lan S.} and Chen, {Peng Sheng}",

year = "2006",

month = jan,

doi = "10.1016/j.hrthm.2005.09.016",

language = "English (US)",

volume = "3",

pages = "78--85",

journal = "Heart Rhythm",

issn = "1547-5271",

publisher = "Elsevier",

number = "1",

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TY - JOUR

T1 - Circadian variations of stellate ganglion nerve activity in ambulatory dogs

AU - Jung, Byung Chun

AU - Dave, Amish S.

AU - Tan, Alex Y.

AU - Gholmieh, Ghassan

AU - Zhou, Shengmei

AU - Wang, David C.

AU - Akingba, A. George

AU - Fishbein, Gregory A.

AU - Montemagno, Carlo

AU - Lin, Shien Fong

AU - Chen, Lan S.

AU - Chen, Peng Sheng

PY - 2006/1

Y1 - 2006/1

N2 - Background: The presence of circadian variations in sympathetic outflow from the stellate ganglia is unclear. Objectives: The purpose of this study was to continuously record stellate ganglion nerve activity (SGNA) in ambulatory dogs. Methods We performed continuous 24-hour left (N = 3) or bilateral (N = 3) SGNA recordings in normal ambulatory dogs using implanted Data Sciences International transmitters. We also performed simultaneous ECG recording (n = 5) or simultaneous ECG and blood pressure recordings (n = 1). Results: The total duration of continuous ambulatory recording averaged 41.5 ± 16.6 days. Five dogs had persistent stable recording, and one dog developed hardware malfunction in week 3. SGNA was followed immediately (<1 second) by heart rate and blood pressure elevation and a reduced standard deviation of consecutive activation cycle length (SDNN) from 236 ± 93 ms to 121 ± 51 ms (P = 0.007). Heart rate correlated significantly with SGNA. When there was a sudden increase of SGNA, the sudden increase occurred bilaterally in 90% of the episodes. Both heart rate and SGNA showed statistically significant (P <.01) circadian variation. Nadolol (20 mg/day for 5 days) reduced average heart rate from 99 ± 8 bpm at baseline to 88 ± 9 bpm (N = 6, P = .001) but did not significantly alter SGNA. Immunohistochemical staining of the stellate ganglia showed tyrosine hydroxylase-positive ganglion cells and nerves at the recording site. Conclusion: There is a circadian variation in sympathetic outflow from canine stellate ganglia. Circadian variation of SGNA is an important cause of circadian variations of cardiac sympathetic tone.

AB - Background: The presence of circadian variations in sympathetic outflow from the stellate ganglia is unclear. Objectives: The purpose of this study was to continuously record stellate ganglion nerve activity (SGNA) in ambulatory dogs. Methods We performed continuous 24-hour left (N = 3) or bilateral (N = 3) SGNA recordings in normal ambulatory dogs using implanted Data Sciences International transmitters. We also performed simultaneous ECG recording (n = 5) or simultaneous ECG and blood pressure recordings (n = 1). Results: The total duration of continuous ambulatory recording averaged 41.5 ± 16.6 days. Five dogs had persistent stable recording, and one dog developed hardware malfunction in week 3. SGNA was followed immediately (<1 second) by heart rate and blood pressure elevation and a reduced standard deviation of consecutive activation cycle length (SDNN) from 236 ± 93 ms to 121 ± 51 ms (P = 0.007). Heart rate correlated significantly with SGNA. When there was a sudden increase of SGNA, the sudden increase occurred bilaterally in 90% of the episodes. Both heart rate and SGNA showed statistically significant (P <.01) circadian variation. Nadolol (20 mg/day for 5 days) reduced average heart rate from 99 ± 8 bpm at baseline to 88 ± 9 bpm (N = 6, P = .001) but did not significantly alter SGNA. Immunohistochemical staining of the stellate ganglia showed tyrosine hydroxylase-positive ganglion cells and nerves at the recording site. Conclusion: There is a circadian variation in sympathetic outflow from canine stellate ganglia. Circadian variation of SGNA is an important cause of circadian variations of cardiac sympathetic tone.

KW - Arrhythmia

KW - Cardiac electrophysiology

KW - Sympathetic nerve activity

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DO - 10.1016/j.hrthm.2005.09.016

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AN - SCOPUS:30444452221

SN - 1547-5271

VL - 3

SP - 78

EP - 85

JO - Heart Rhythm

JF - Heart Rhythm

IS - 1

ER -

Circadian variations of stellate ganglion nerve activity in ambulatory dogs

Abstract

Keywords

ASJC Scopus subject areas

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