CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets

Xiao Ling Chen; Quan Dan Tan; Ke Jie Chen; Dan Ni Zheng; Hong Wei Deng; Song He; Feng Kai Mao; Jun Li Hao; Wei Dong Le; Jie Yang

doi:10.1007/s11064-023-04077-6

CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets

Xiao Ling Chen, Quan Dan Tan, Ke Jie Chen, Dan Ni Zheng, Hong Wei Deng, Song He, Feng Kai Mao, Jun Li Hao, Wei Dong Le, Jie Yang

Research output: Contribution to journal › Review article › peer-review

Abstract

Stroke, the second-largest cause of death and the leading cause of disability globally, presents significant challenges in terms of prognosis and treatment. Identifying reliable prognosis biomarkers and treatment targets is crucial to address these challenges. Circular RNA (circRNA) has emerged as a promising research biomarkers and therapeutic targets because of its tissue specificity and conservation. However, the potential role of circRNA in stroke prognosis and treatment remains largely unexplored. This review briefly elucidate the mechanism underlying circRNA’s involvement in stroke pathophysiology. Additionally, this review summarizes the impact of circRNA on different forms of strokes, including ischemic stroke and hemorrhagic stroke. And, this article discusses the positive effects of circRNA on promoting cerebrovascular repair and regeneration, maintaining the integrity of the blood-brain barrier (BBB), and reducing neuronal injury and immune inflammatory response. In conclusion, the significance of circRNA as a potential prognostic biomarker and a viable therapeutic target was underscored.

Original language	English (US)
Pages (from-to)	557-567
Number of pages	11
Journal	Neurochemical Research
Volume	49
Issue number	3
DOIs	https://doi.org/10.1007/s11064-023-04077-6
State	Published - Mar 2024

Keywords

Biomarker
CircRNA
Stroke
Therapeutic Target

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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abstract = "Stroke, the second-largest cause of death and the leading cause of disability globally, presents significant challenges in terms of prognosis and treatment. Identifying reliable prognosis biomarkers and treatment targets is crucial to address these challenges. Circular RNA (circRNA) has emerged as a promising research biomarkers and therapeutic targets because of its tissue specificity and conservation. However, the potential role of circRNA in stroke prognosis and treatment remains largely unexplored. This review briefly elucidate the mechanism underlying circRNA{\textquoteright}s involvement in stroke pathophysiology. Additionally, this review summarizes the impact of circRNA on different forms of strokes, including ischemic stroke and hemorrhagic stroke. And, this article discusses the positive effects of circRNA on promoting cerebrovascular repair and regeneration, maintaining the integrity of the blood-brain barrier (BBB), and reducing neuronal injury and immune inflammatory response. In conclusion, the significance of circRNA as a potential prognostic biomarker and a viable therapeutic target was underscored.",

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author = "Chen, {Xiao Ling} and Tan, {Quan Dan} and Chen, {Ke Jie} and Zheng, {Dan Ni} and Deng, {Hong Wei} and Song He and Mao, {Feng Kai} and Hao, {Jun Li} and Le, {Wei Dong} and Jie Yang",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.",

year = "2024",

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doi = "10.1007/s11064-023-04077-6",

language = "English (US)",

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T2 - New Insight of Potential Biomarkers and Therapeutic Targets

AU - Chen, Xiao Ling

AU - Tan, Quan Dan

AU - Chen, Ke Jie

AU - Zheng, Dan Ni

AU - Deng, Hong Wei

AU - He, Song

AU - Mao, Feng Kai

AU - Hao, Jun Li

AU - Le, Wei Dong

AU - Yang, Jie

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.

PY - 2024/3

Y1 - 2024/3

N2 - Stroke, the second-largest cause of death and the leading cause of disability globally, presents significant challenges in terms of prognosis and treatment. Identifying reliable prognosis biomarkers and treatment targets is crucial to address these challenges. Circular RNA (circRNA) has emerged as a promising research biomarkers and therapeutic targets because of its tissue specificity and conservation. However, the potential role of circRNA in stroke prognosis and treatment remains largely unexplored. This review briefly elucidate the mechanism underlying circRNA’s involvement in stroke pathophysiology. Additionally, this review summarizes the impact of circRNA on different forms of strokes, including ischemic stroke and hemorrhagic stroke. And, this article discusses the positive effects of circRNA on promoting cerebrovascular repair and regeneration, maintaining the integrity of the blood-brain barrier (BBB), and reducing neuronal injury and immune inflammatory response. In conclusion, the significance of circRNA as a potential prognostic biomarker and a viable therapeutic target was underscored.

AB - Stroke, the second-largest cause of death and the leading cause of disability globally, presents significant challenges in terms of prognosis and treatment. Identifying reliable prognosis biomarkers and treatment targets is crucial to address these challenges. Circular RNA (circRNA) has emerged as a promising research biomarkers and therapeutic targets because of its tissue specificity and conservation. However, the potential role of circRNA in stroke prognosis and treatment remains largely unexplored. This review briefly elucidate the mechanism underlying circRNA’s involvement in stroke pathophysiology. Additionally, this review summarizes the impact of circRNA on different forms of strokes, including ischemic stroke and hemorrhagic stroke. And, this article discusses the positive effects of circRNA on promoting cerebrovascular repair and regeneration, maintaining the integrity of the blood-brain barrier (BBB), and reducing neuronal injury and immune inflammatory response. In conclusion, the significance of circRNA as a potential prognostic biomarker and a viable therapeutic target was underscored.

KW - Biomarker

KW - CircRNA

KW - Stroke

KW - Therapeutic Target

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CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets

Abstract

Keywords

ASJC Scopus subject areas

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