TY - JOUR
T1 - Clinical features of Parkinson's disease with and without rapid eye movement sleep behavior disorder
AU - Liu, Ye
AU - Zhu, Xiao Ying
AU - Zhang, Xiao Jin
AU - Kuo, Sheng Han
AU - Ondo, William G.
AU - Wu, Yun Cheng
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (NSFC) (81171205, 81371410) and the Biomedical Multidisciplinary Program of Shanghai Jiao Tong University (YG2014MS31, YG2015QN21, YG2016QN25).
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/21
Y1 - 2017/12/21
N2 - Background: Rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confirm the clinical features of RBD in Chinese PD patients. Methods: One hundred fifty PD patients were enrolled from the Parkinson's disease and Movement Disorders Centerin Department of Neurology, Shanghai General Hospital from January 2013 to August 2014. This study examined PD patients with or without RBD as determined by the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), assessed motor subtype by Unified PD Rating Scale (UPDRS) III at "on" state, and compared the sub-scale scores representing tremor, rigidity, appendicular and axial. Investigators also assessed the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Parkinson's disease Sleep Scale (PDSS). Results: One hundred fourty one PD patients entered the final study. 30 (21.28%) PD patients had probable RBD (pRBD) diagnosed with a RBDSQ score of 6 or above. There were no significant differences for age, including age of PD onset and PD duration, gender, smoking status, alcohol or coffee use, presence of anosmia or freezing, UPDRS III, and H-Y stages between the pRBD+ and pRBD- groups. pRBD+ group had lower MMSE scores, higher PDSS scores, and pRBD+ PD patients had more prominent proportion in anxiety, depression, constipation, hallucination and a greater prevalence of orthostatic hypotension. Conclusion: pRBD+ PD patients exhibited greater changes in non-motor symptoms. However, there was no increase in motor deficits.
AB - Background: Rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confirm the clinical features of RBD in Chinese PD patients. Methods: One hundred fifty PD patients were enrolled from the Parkinson's disease and Movement Disorders Centerin Department of Neurology, Shanghai General Hospital from January 2013 to August 2014. This study examined PD patients with or without RBD as determined by the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), assessed motor subtype by Unified PD Rating Scale (UPDRS) III at "on" state, and compared the sub-scale scores representing tremor, rigidity, appendicular and axial. Investigators also assessed the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Parkinson's disease Sleep Scale (PDSS). Results: One hundred fourty one PD patients entered the final study. 30 (21.28%) PD patients had probable RBD (pRBD) diagnosed with a RBDSQ score of 6 or above. There were no significant differences for age, including age of PD onset and PD duration, gender, smoking status, alcohol or coffee use, presence of anosmia or freezing, UPDRS III, and H-Y stages between the pRBD+ and pRBD- groups. pRBD+ group had lower MMSE scores, higher PDSS scores, and pRBD+ PD patients had more prominent proportion in anxiety, depression, constipation, hallucination and a greater prevalence of orthostatic hypotension. Conclusion: pRBD+ PD patients exhibited greater changes in non-motor symptoms. However, there was no increase in motor deficits.
KW - Cognitive decline
KW - Depression
KW - Motor deficits
KW - Orthostatic hypotension
KW - Parkinson's disease
KW - Rapid eye movement sleep behavior disorder
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U2 - 10.1186/s40035-017-0105-5
DO - 10.1186/s40035-017-0105-5
M3 - Article
AN - SCOPUS:85038610064
SN - 2047-9158
VL - 6
JO - Translational Neurodegeneration
JF - Translational Neurodegeneration
IS - 1
M1 - 35
ER -