TY - JOUR
T1 - Clinical implications of skeletal muscle blood-oxygenation-level-dependent (BOLD) MRI
AU - Partovi, Sasan
AU - Karimi, Sasan
AU - Jacobi, Bjoern
AU - Schulte, Anja Carina
AU - Aschwanden, Markus
AU - Zipp, Lisa
AU - Lyo, John K.
AU - Karmonik, Christof
AU - Müller-Eschner, Matthias
AU - Huegli, Rolf W.
AU - Bongartz, Georg
AU - Bilecen, Deniz
PY - 2012/8
Y1 - 2012/8
N2 - Blood-oxygenation-level-dependent (BOLD) contrast in magnetic resonance (MR) imaging of skeletal muscle mainly depends on changes of oxygen saturation in the microcirculation. In recent years, an increasing number of studies have evaluated the clinical relevance of skeletal muscle BOLD MR imaging in vascular diseases, such as peripheral arterial occlusive disease, diabetes mellitus, and chronic compartment syndrome. BOLD imaging combines the advantages of MR imaging, i.e., high spatial resolution, no exposure to ionizing radiation, with functional information of local microvascular perfusion. Due to intrinsic contrast provoked via changes in hemoglobin oxygen saturation, it is a safe and easy applicable procedure on standard whole-body MR devices. Therefore, BOLD MR imaging of skeletal muscle is a potential new diagnostic tool in the clinical evaluation of vascular, inflammatory, and muscular pathologies. Our review focuses on the current evidence concerning the use of BOLD MR imaging of skeletal muscle under pathological conditions and highlights ways for future clinical and scientific applications.
AB - Blood-oxygenation-level-dependent (BOLD) contrast in magnetic resonance (MR) imaging of skeletal muscle mainly depends on changes of oxygen saturation in the microcirculation. In recent years, an increasing number of studies have evaluated the clinical relevance of skeletal muscle BOLD MR imaging in vascular diseases, such as peripheral arterial occlusive disease, diabetes mellitus, and chronic compartment syndrome. BOLD imaging combines the advantages of MR imaging, i.e., high spatial resolution, no exposure to ionizing radiation, with functional information of local microvascular perfusion. Due to intrinsic contrast provoked via changes in hemoglobin oxygen saturation, it is a safe and easy applicable procedure on standard whole-body MR devices. Therefore, BOLD MR imaging of skeletal muscle is a potential new diagnostic tool in the clinical evaluation of vascular, inflammatory, and muscular pathologies. Our review focuses on the current evidence concerning the use of BOLD MR imaging of skeletal muscle under pathological conditions and highlights ways for future clinical and scientific applications.
KW - Blood-oxygenation-level-dependent MRI
KW - BOLD effect
KW - Paradigms
KW - Percutaneous transluminal angioplasty
KW - Peripheral arterial occlusive disease
UR - http://www.scopus.com/inward/record.url?scp=84864982887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864982887&partnerID=8YFLogxK
U2 - 10.1007/s10334-012-0306-y
DO - 10.1007/s10334-012-0306-y
M3 - Review article
C2 - 22374263
AN - SCOPUS:84864982887
SN - 0968-5243
VL - 25
SP - 251
EP - 261
JO - Magnetic Resonance Materials in Physics, Biology and Medicine
JF - Magnetic Resonance Materials in Physics, Biology and Medicine
IS - 4
ER -