TY - JOUR
T1 - Clinical Outcomes of Liver Transplantation in Patients With Hepatorenal Syndrome
T2 - A Single Center Study in China
AU - Li, Fangcong
AU - Wang, Tielong
AU - Zhan, Liqiang
AU - Jia, Zehua
AU - Luo, Tao
AU - Chen, Shirui
AU - Zhao, Qiang
AU - Guo, Zhiyong
AU - He, Xiaoshun
AU - Wang, Dongping
N1 - Publisher Copyright:
Copyright © 2022 Li, Wang, Zhan, Jia, Luo, Chen, Zhao, Guo, He and Wang.
PY - 2022/1/28
Y1 - 2022/1/28
N2 - Background: Liver transplantation (LT) is an optimal treatment for hepatorenal syndrome (HRS) patients but renal function recovery is not universal after operation. The aim of this study is to explore the association between stages of hepatorenal syndrome—acute kidney injury (HRS-AKI) and incidence of post-operation chronic kidney disease (CKD). Methods: Data of HRS-AKI patients who received LT were collected from the First Affiliated Hospital of Sun Yat-sen University from 2016 to 2020. A survival and incidence curve and multivariable model were established to analyze the impacts of HRS-AKI stages and variables on 90-day survival and CKD within 12 months. Results: A total of 62 HRS-AKI patients were enrolled in this study. Overall, 35 (57%), 17 (27%), and 10 (16%) patients were diagnosed as stages 1, 2, and 3, respectively. The patients at stage 3 had the poorest outcomes with the lowest rate of 90-day survival and the highest incidence of CKD in 12 months. Stage 3 (SHR = 7.186, 95% CI, 1.661–32.043) and postoperative renal replacement therapy (RRT) (SHR = 3.228, 95% CI, 1.115–9.345) were found as useful indicators for poor prognosis. Conclusions: In our study, the classification of HRS-AKI stages can be used to predict the prognosis of HRS patients after LT. The peak serum creatinine level is a risky predictor in high HRS-AKI stage patients.
AB - Background: Liver transplantation (LT) is an optimal treatment for hepatorenal syndrome (HRS) patients but renal function recovery is not universal after operation. The aim of this study is to explore the association between stages of hepatorenal syndrome—acute kidney injury (HRS-AKI) and incidence of post-operation chronic kidney disease (CKD). Methods: Data of HRS-AKI patients who received LT were collected from the First Affiliated Hospital of Sun Yat-sen University from 2016 to 2020. A survival and incidence curve and multivariable model were established to analyze the impacts of HRS-AKI stages and variables on 90-day survival and CKD within 12 months. Results: A total of 62 HRS-AKI patients were enrolled in this study. Overall, 35 (57%), 17 (27%), and 10 (16%) patients were diagnosed as stages 1, 2, and 3, respectively. The patients at stage 3 had the poorest outcomes with the lowest rate of 90-day survival and the highest incidence of CKD in 12 months. Stage 3 (SHR = 7.186, 95% CI, 1.661–32.043) and postoperative renal replacement therapy (RRT) (SHR = 3.228, 95% CI, 1.115–9.345) were found as useful indicators for poor prognosis. Conclusions: In our study, the classification of HRS-AKI stages can be used to predict the prognosis of HRS patients after LT. The peak serum creatinine level is a risky predictor in high HRS-AKI stage patients.
KW - AKI
KW - CKD
KW - HRS
KW - acute kidney injury
KW - chronic kidney disease
KW - hepatorenal syndrome
KW - liver transplantation
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U2 - 10.3389/fsurg.2021.781648
DO - 10.3389/fsurg.2021.781648
M3 - Article
AN - SCOPUS:85124536226
SN - 2296-875X
VL - 8
JO - Frontiers in Surgery
JF - Frontiers in Surgery
M1 - 781648
ER -