TY - JOUR
T1 - Clinical stage i nonseminomatous and mixed germ cell tumors of the testis. A clinicopathologic study of 93 patients on a surveillance protocol after orchiectomy alone
AU - Dunphy, Cherie H.
AU - Ayala, Alberto G.
AU - Swanson, David A.
AU - Ro, Jae Y.
AU - Logothetis, Christopher
PY - 1988/9/15
Y1 - 1988/9/15
N2 - This study of 93 patients with Stage I nonseminomatous and mixed germ cell testicular tumors who were placed in a surveillance study following orchiectomy was designed to evaluate pathologic prognostic factors. Follow-up was at least 12 months postorchiectomy except for one patient who was followed for 9 months. Lymphatic invasion was identified in 26 patients, 62% of whom developed distant metastases; metastasis developed in only 18% of 67 patients without lymphatic invasion (P < 0.01). Relapse was also associated with the presence of embryonal carcinoma. Of 81 patients with an embryonal carcinoma component, 35% developed metastases, whereas none of those without an embryonal carcinoma developed metastasis (P = 0.05). Effects of other histologic features and tumor size were not significant. Lymphatic invasion appeared to be a significant poor prognostic factor, and embryonal carcinoma was an independent poor prognostic factor.
AB - This study of 93 patients with Stage I nonseminomatous and mixed germ cell testicular tumors who were placed in a surveillance study following orchiectomy was designed to evaluate pathologic prognostic factors. Follow-up was at least 12 months postorchiectomy except for one patient who was followed for 9 months. Lymphatic invasion was identified in 26 patients, 62% of whom developed distant metastases; metastasis developed in only 18% of 67 patients without lymphatic invasion (P < 0.01). Relapse was also associated with the presence of embryonal carcinoma. Of 81 patients with an embryonal carcinoma component, 35% developed metastases, whereas none of those without an embryonal carcinoma developed metastasis (P = 0.05). Effects of other histologic features and tumor size were not significant. Lymphatic invasion appeared to be a significant poor prognostic factor, and embryonal carcinoma was an independent poor prognostic factor.
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U2 - 10.1002/1097-0142(19880915)62:6<1202::AID-CNCR2820620627>3.0.CO;2-S
DO - 10.1002/1097-0142(19880915)62:6<1202::AID-CNCR2820620627>3.0.CO;2-S
M3 - Article
C2 - 2842034
AN - SCOPUS:0023759411
SN - 0008-543X
VL - 62
SP - 1202
EP - 1206
JO - Cancer
JF - Cancer
IS - 6
ER -