Abstract
Objective: The objective of the study was to explore the effect of African American race on survival following radical hysterectomy for cervical cancer. Study Design: We reviewed all cases of stage IA-IIA cervical cancer treated with radical hysterectomy at our institution (1987-2001). Characteristics between races were compared using Mann Whitney U and χ2 tests. Hazard ratios (HR) of survival were calculated using Cox regression. Results: We identified 134 Caucasian and 66 African American patients. There was a trend toward worse survival among African Americans (81.8% vs 88.8%, P = .165). An interaction effect between race and depth of stromal invasion was observed (P = .005), and the combination of African American race and deep stromal invasion had a powerful, independent effect on survival (HR of death 7.04 [95% confidence interval 2.48 to 19.94]). Conclusion: The combination of African American race and deep stromal invasion has an adverse effect on survival following radical hysterectomy for cervical cancer and may warrant use of adjuvant therapy.
Original language | English (US) |
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Pages (from-to) | 196.e1-196.e7 |
Journal | American Journal of Obstetrics and Gynecology |
Volume | 199 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2008 |
Keywords
- African American race
- cervical cancer
- depth of stromal invasion
- radical hysterectomy
ASJC Scopus subject areas
- Obstetrics and Gynecology