Combined Hepatocellular-Cholangiocarcinoma: An Update on Pathology and Diagnostic Approach

Joon Hyuk Choi; Jae Y. Ro

doi:10.3390/biomedicines10081826

Combined Hepatocellular-Cholangiocarcinoma: An Update on Pathology and Diagnostic Approach

Joon Hyuk Choi, Jae Y. Ro

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma displaying both hepatocytic and cholangiocytic differentiation within the same tumor. Relative to classic hepatocellular carcinoma (HCC), cHCC-CCA has more aggressive behavior and a poorer prognosis. Though recent advances have improved our understanding of the biology underlying cHCC-CCAs, they remain diagnostically challenging for pathologists because of their morphologic and phenotypic diversity. Accurate diagnosis of cHCC-CCA is important for patient management and prognostication. Herein, we review recent updates on cHCC-CCA, focusing on tumor classification, pathology, and diagnostic approach.

Original language	English (US)
Article number	1826
Journal	Biomedicines
Volume	10
Issue number	8
DOIs	https://doi.org/10.3390/biomedicines10081826
State	Published - Jul 29 2022

Keywords

adult
cholangiocarcinoma
combined hepatocellular-cholangiocarcinoma
hepatocellular carcinoma
liver cancers

ASJC Scopus subject areas

Medicine (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.3390/biomedicines10081826

Cite this

@article{e5dacf7d5b944927b61e204e7b7e0460,

title = "Combined Hepatocellular-Cholangiocarcinoma: An Update on Pathology and Diagnostic Approach",

abstract = "Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma displaying both hepatocytic and cholangiocytic differentiation within the same tumor. Relative to classic hepatocellular carcinoma (HCC), cHCC-CCA has more aggressive behavior and a poorer prognosis. Though recent advances have improved our understanding of the biology underlying cHCC-CCAs, they remain diagnostically challenging for pathologists because of their morphologic and phenotypic diversity. Accurate diagnosis of cHCC-CCA is important for patient management and prognostication. Herein, we review recent updates on cHCC-CCA, focusing on tumor classification, pathology, and diagnostic approach.",

keywords = "adult, cholangiocarcinoma, combined hepatocellular-cholangiocarcinoma, hepatocellular carcinoma, liver cancers",

author = "Choi, {Joon Hyuk} and Ro, {Jae Y.}",

note = "Funding Information: This work was supported by the 2021 Yeungnam University Research Grant. Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = jul,

day = "29",

doi = "10.3390/biomedicines10081826",

language = "English (US)",

volume = "10",

journal = "Biomedicines",

issn = "2227-9059",

publisher = "MDPI AG",

number = "8",

}

TY - JOUR

T1 - Combined Hepatocellular-Cholangiocarcinoma

T2 - An Update on Pathology and Diagnostic Approach

AU - Choi, Joon Hyuk

AU - Ro, Jae Y.

PY - 2022/7/29

Y1 - 2022/7/29

N2 - Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma displaying both hepatocytic and cholangiocytic differentiation within the same tumor. Relative to classic hepatocellular carcinoma (HCC), cHCC-CCA has more aggressive behavior and a poorer prognosis. Though recent advances have improved our understanding of the biology underlying cHCC-CCAs, they remain diagnostically challenging for pathologists because of their morphologic and phenotypic diversity. Accurate diagnosis of cHCC-CCA is important for patient management and prognostication. Herein, we review recent updates on cHCC-CCA, focusing on tumor classification, pathology, and diagnostic approach.

AB - Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma displaying both hepatocytic and cholangiocytic differentiation within the same tumor. Relative to classic hepatocellular carcinoma (HCC), cHCC-CCA has more aggressive behavior and a poorer prognosis. Though recent advances have improved our understanding of the biology underlying cHCC-CCAs, they remain diagnostically challenging for pathologists because of their morphologic and phenotypic diversity. Accurate diagnosis of cHCC-CCA is important for patient management and prognostication. Herein, we review recent updates on cHCC-CCA, focusing on tumor classification, pathology, and diagnostic approach.

KW - adult

KW - cholangiocarcinoma

KW - combined hepatocellular-cholangiocarcinoma

KW - hepatocellular carcinoma

KW - liver cancers

UR - http://www.scopus.com/inward/record.url?scp=85137378685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85137378685&partnerID=8YFLogxK

U2 - 10.3390/biomedicines10081826

DO - 10.3390/biomedicines10081826

M3 - Review article

C2 - 36009374

AN - SCOPUS:85137378685

SN - 2227-9059

VL - 10

JO - Biomedicines

JF - Biomedicines

IS - 8

M1 - 1826

ER -

Combined Hepatocellular-Cholangiocarcinoma: An Update on Pathology and Diagnostic Approach

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this