@inproceedings{5cd73234b62b4fc7b0d4f2f386c6abb4,
title = "Computational model for simulation of left ventricle behaviour during heart beat",
abstract = "The heart is a complex organ which produces mechanical force needed for the blood flow. Electrical signals are transformed into active stresses which contract the heart muscle and pump the blood out from the left ventricle. Therefore, comprehensive numerical procedure has to be established in order to simulate this process and to investigate the effects of different drugs on heart behavior. We here present application of the finite element (FE) computational model for simulation of heart beat cycle of the parametric left ventricle model. We are using Hunter excitation model for active, and direct experimental constitute relations for passive mechanical stresses. Additionally, computational model includes hysteretic and compressible behavior according to the experimental investigations. Applicability of our computational model is demonstrated using parametric left ventricle model which includes inlet mitral and outlet aortic valve cross-sections. With using different boundary conditions and prescribed values, this model has potential to mimic the effects of different drugs on heart beat cycle.",
keywords = "finite element model, heart model, left ventricle, loose coupling",
author = "Miljan Milosevic and Bogdan Milicevic and Vladimir Simic and Vladimir Geroski and Nenad Filipovic and Milos Kojic",
note = "Funding Information: This paper is supported by the SILICOFCM project that Publisher Copyright: {\textcopyright} 2021 IEEE.; 21st IEEE International Conference on BioInformatics and BioEngineering, BIBE 2021 ; Conference date: 25-10-2021 Through 27-10-2021",
year = "2021",
doi = "10.1109/BIBE52308.2021.9635417",
language = "English (US)",
series = "BIBE 2021 - 21st IEEE International Conference on BioInformatics and BioEngineering, Proceedings",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "BIBE 2021 - 21st IEEE International Conference on BioInformatics and BioEngineering, Proceedings",
address = "United States",
}