Concentration effect on the diffusion of glucose in ocular tissues

Mohamad G. Ghosn; Esteban F. Carbajal; Natasha A. Befrui; Valery V. Tuchin; Kirill V. Larin

doi:10.1016/j.optlaseng.2008.05.004

Concentration effect on the diffusion of glucose in ocular tissues

Mohamad G. Ghosn, Esteban F. Carbajal, Natasha A. Befrui, Valery V. Tuchin, Kirill V. Larin

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In this study, optical coherence tomography (OCT) was utilized in the functional imaging of glucose diffusion through scleral tissues. Permeability coefficients for different concentrations of glucose were quantified nondestructively. Obtained results indicate an inverse proportionality between the permeability coefficient and the concentration of the analyte in epithelial tissues: in-depth diffusion of solutions with lower glucose concentration was faster than those with a higher concentration. The permeability coefficient decreased from (1.67±0.17)×10^-5 cm/s of 10% glucose solution to (5.08±0.23)×10^-6 cm/s of 25% glucose solution. The dependence of the permeability on the concentration of hyperosmotic analytes could potentially be used in various basic science and clinical fields, such as optical clearing of tissues and cells as well as in clinical pharmacology.

Original language	English (US)
Pages (from-to)	911-914
Number of pages	4
Journal	Optics and Lasers in Engineering
Volume	46
Issue number	12
DOIs	https://doi.org/10.1016/j.optlaseng.2008.05.004
State	Published - Dec 2008

Keywords

Concentration
Glucose
Optical coherence tomography
Permeability
Sclera

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Mechanical Engineering
Electrical and Electronic Engineering

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10.1016/j.optlaseng.2008.05.004

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title = "Concentration effect on the diffusion of glucose in ocular tissues",

abstract = "In this study, optical coherence tomography (OCT) was utilized in the functional imaging of glucose diffusion through scleral tissues. Permeability coefficients for different concentrations of glucose were quantified nondestructively. Obtained results indicate an inverse proportionality between the permeability coefficient and the concentration of the analyte in epithelial tissues: in-depth diffusion of solutions with lower glucose concentration was faster than those with a higher concentration. The permeability coefficient decreased from (1.67±0.17)×10-5 cm/s of 10% glucose solution to (5.08±0.23)×10-6 cm/s of 25% glucose solution. The dependence of the permeability on the concentration of hyperosmotic analytes could potentially be used in various basic science and clinical fields, such as optical clearing of tissues and cells as well as in clinical pharmacology.",

keywords = "Concentration, Glucose, Optical coherence tomography, Permeability, Sclera",

author = "Ghosn, {Mohamad G.} and Carbajal, {Esteban F.} and Befrui, {Natasha A.} and Tuchin, {Valery V.} and Larin, {Kirill V.}",

note = "Funding Information: The study was supported in part by grants from W. Coulter Foundation and Office of Naval Research (KVL) and Federal Agency of Education of RF no. 1.4.06, RNP.2.1.1.4473 and by CRDF BRHE Grant RUXO-006-SR-06 (VVT). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2008",

month = dec,

doi = "10.1016/j.optlaseng.2008.05.004",

language = "English (US)",

volume = "46",

pages = "911--914",

journal = "Optics and Lasers in Engineering",

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AU - Ghosn, Mohamad G.

AU - Carbajal, Esteban F.

AU - Befrui, Natasha A.

AU - Tuchin, Valery V.

AU - Larin, Kirill V.

N1 - Funding Information: The study was supported in part by grants from W. Coulter Foundation and Office of Naval Research (KVL) and Federal Agency of Education of RF no. 1.4.06, RNP.2.1.1.4473 and by CRDF BRHE Grant RUXO-006-SR-06 (VVT). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2008/12

Y1 - 2008/12

N2 - In this study, optical coherence tomography (OCT) was utilized in the functional imaging of glucose diffusion through scleral tissues. Permeability coefficients for different concentrations of glucose were quantified nondestructively. Obtained results indicate an inverse proportionality between the permeability coefficient and the concentration of the analyte in epithelial tissues: in-depth diffusion of solutions with lower glucose concentration was faster than those with a higher concentration. The permeability coefficient decreased from (1.67±0.17)×10-5 cm/s of 10% glucose solution to (5.08±0.23)×10-6 cm/s of 25% glucose solution. The dependence of the permeability on the concentration of hyperosmotic analytes could potentially be used in various basic science and clinical fields, such as optical clearing of tissues and cells as well as in clinical pharmacology.

AB - In this study, optical coherence tomography (OCT) was utilized in the functional imaging of glucose diffusion through scleral tissues. Permeability coefficients for different concentrations of glucose were quantified nondestructively. Obtained results indicate an inverse proportionality between the permeability coefficient and the concentration of the analyte in epithelial tissues: in-depth diffusion of solutions with lower glucose concentration was faster than those with a higher concentration. The permeability coefficient decreased from (1.67±0.17)×10-5 cm/s of 10% glucose solution to (5.08±0.23)×10-6 cm/s of 25% glucose solution. The dependence of the permeability on the concentration of hyperosmotic analytes could potentially be used in various basic science and clinical fields, such as optical clearing of tissues and cells as well as in clinical pharmacology.

KW - Concentration

KW - Glucose

KW - Optical coherence tomography

KW - Permeability

KW - Sclera

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JO - Optics and Lasers in Engineering

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ER -

Concentration effect on the diffusion of glucose in ocular tissues

Abstract

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