Abstract
BACKGROUND: Paternal dispermy can be the pathogenesis of complete molar pregnancy. CASE: A 23-year-old, white woman, gravida 4, para 1, was pregnant with a twin gestation by ovulation induction with metrodin. Ultrasound evaluation confirmed an intrauterine pregnancy in conjunction with what appeared to be a hydatidiform mole. The karyotype in the molar pregnancy, obtained from chorionic villus sampling, showed a pair of paternally derived inverted chromosomes 9, confirming the diagnosis of a complete mole. Uncontrollable hemorrhage with a rapid rise in the β-human chorionic gonadotropin titer necessitated evacuation of the uterus. The patient was followed with β-human chorionic gonadotropin titers for a year, with no evidence of recurrence. CONCLUSION: This case illustrates paternal disomy in a complete molar pregnancy documented by a paternal chromosome 9 inversion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 39-41 |
| Number of pages | 3 |
| Journal | Journal of Reproductive Medicine for the Obstetrician and Gynecologist |
| Volume | 45 |
| Issue number | 1 |
| State | Published - Jan 1 2000 |
Keywords
- Hydatidiform mole
- Inversion (genetics)
- Ovulation induction
- Prenatal diagnosis
- Uniparental disomy
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Reproductive Medicine