Coronary Artery Disease and Aspirin Intolerance: Background and Insights on Current Management

Ravi A. Thakker; Leonardo Salazar; Deaa Abu Jazar; Pooja Bhakta; Bryan Baker; Chandani Patel; Ayman Elbadawi; Mayank Agarwal; Aiham Albaeni; Mohammed Saleh; Jonathan Esclovan; Danielle El Haddad; Hashim Alwash; Ankur Kalra; Sachin S. Goel; Robert Jay Widmer; Khaled Chatila; Wissam Khalife; Afaq Motiwala; Jennifer McCracken; Hani Jneid; Syed Gilani

doi:10.1007/s40119-022-00255-9

Coronary Artery Disease and Aspirin Intolerance: Background and Insights on Current Management

Ravi A. Thakker, Leonardo Salazar, Deaa Abu Jazar, Pooja Bhakta, Bryan Baker, Chandani Patel, Ayman Elbadawi, Mayank Agarwal, Aiham Albaeni, Mohammed Saleh, Jonathan Esclovan, Danielle El Haddad, Hashim Alwash, Ankur Kalra, Sachin S. Goel, Robert Jay Widmer, Khaled Chatila, Wissam Khalife, Afaq Motiwala, Jennifer McCrackenHani Jneid, Syed Gilani

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Aspirin is one of the most widely used medications across the global healthcare system and is the foundation in treating ischemic heart disease, as well as secondary prevention for ischemic and valvular heart disease. Challenges arise in treating patients with cardiovascular disease who have concomitant aspirin intolerance. Through an extensive review of the literature, we provide a comprehensive background on the pharmacology of aspirin, the mechanisms behind aspirin intolerance, the importance of aspirin in cardiovascular disease, and the management of aspirin intolerance in both acute coronary syndrome and stable coronary artery disease. Our review includes a multidisciplinary approach from the internist, allergist/immunologist, and cardiologist when evaluating this important patient population.

Original language	English (US)
Pages (from-to)	175-183
Number of pages	9
Journal	Cardiology and Therapy
Volume	11
Issue number	2
DOIs	https://doi.org/10.1007/s40119-022-00255-9
State	Published - Jun 2022

Keywords

Acute coronary syndrome
Aspirin intolerance
Coronary artery disease

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1007/s40119-022-00255-9

Cite this

Thakker, R. A., Salazar, L., Jazar, D. A., Bhakta, P., Baker, B., Patel, C., Elbadawi, A., Agarwal, M., Albaeni, A., Saleh, M., Esclovan, J., El Haddad, D., Alwash, H., Kalra, A., Goel, S. S., Widmer, R. J., Chatila, K., Khalife, W., Motiwala, A., ... Gilani, S. (2022). Coronary Artery Disease and Aspirin Intolerance: Background and Insights on Current Management. Cardiology and Therapy, 11(2), 175-183. https://doi.org/10.1007/s40119-022-00255-9

Thakker, RA, Salazar, L, Jazar, DA, Bhakta, P, Baker, B, Patel, C, Elbadawi, A, Agarwal, M, Albaeni, A, Saleh, M, Esclovan, J, El Haddad, D, Alwash, H, Kalra, A, Goel, SS, Widmer, RJ, Chatila, K, Khalife, W, Motiwala, A, McCracken, J, Jneid, H & Gilani, S 2022, 'Coronary Artery Disease and Aspirin Intolerance: Background and Insights on Current Management', Cardiology and Therapy, vol. 11, no. 2, pp. 175-183. https://doi.org/10.1007/s40119-022-00255-9

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abstract = "Aspirin is one of the most widely used medications across the global healthcare system and is the foundation in treating ischemic heart disease, as well as secondary prevention for ischemic and valvular heart disease. Challenges arise in treating patients with cardiovascular disease who have concomitant aspirin intolerance. Through an extensive review of the literature, we provide a comprehensive background on the pharmacology of aspirin, the mechanisms behind aspirin intolerance, the importance of aspirin in cardiovascular disease, and the management of aspirin intolerance in both acute coronary syndrome and stable coronary artery disease. Our review includes a multidisciplinary approach from the internist, allergist/immunologist, and cardiologist when evaluating this important patient population.",

keywords = "Acute coronary syndrome, Aspirin intolerance, Coronary artery disease",

author = "Thakker, {Ravi A.} and Leonardo Salazar and Jazar, {Deaa Abu} and Pooja Bhakta and Bryan Baker and Chandani Patel and Ayman Elbadawi and Mayank Agarwal and Aiham Albaeni and Mohammed Saleh and Jonathan Esclovan and {El Haddad}, Danielle and Hashim Alwash and Ankur Kalra and Goel, {Sachin S.} and Widmer, {Robert Jay} and Khaled Chatila and Wissam Khalife and Afaq Motiwala and Jennifer McCracken and Hani Jneid and Syed Gilani",

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doi = "10.1007/s40119-022-00255-9",

language = "English (US)",

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AU - Thakker, Ravi A.

AU - Salazar, Leonardo

AU - Jazar, Deaa Abu

AU - Bhakta, Pooja

AU - Baker, Bryan

AU - Patel, Chandani

AU - Elbadawi, Ayman

AU - Agarwal, Mayank

AU - Albaeni, Aiham

AU - Saleh, Mohammed

AU - Esclovan, Jonathan

AU - El Haddad, Danielle

AU - Alwash, Hashim

AU - Kalra, Ankur

AU - Goel, Sachin S.

AU - Widmer, Robert Jay

AU - Chatila, Khaled

AU - Khalife, Wissam

AU - Motiwala, Afaq

AU - McCracken, Jennifer

AU - Jneid, Hani

AU - Gilani, Syed

PY - 2022/6

Y1 - 2022/6

N2 - Aspirin is one of the most widely used medications across the global healthcare system and is the foundation in treating ischemic heart disease, as well as secondary prevention for ischemic and valvular heart disease. Challenges arise in treating patients with cardiovascular disease who have concomitant aspirin intolerance. Through an extensive review of the literature, we provide a comprehensive background on the pharmacology of aspirin, the mechanisms behind aspirin intolerance, the importance of aspirin in cardiovascular disease, and the management of aspirin intolerance in both acute coronary syndrome and stable coronary artery disease. Our review includes a multidisciplinary approach from the internist, allergist/immunologist, and cardiologist when evaluating this important patient population.

AB - Aspirin is one of the most widely used medications across the global healthcare system and is the foundation in treating ischemic heart disease, as well as secondary prevention for ischemic and valvular heart disease. Challenges arise in treating patients with cardiovascular disease who have concomitant aspirin intolerance. Through an extensive review of the literature, we provide a comprehensive background on the pharmacology of aspirin, the mechanisms behind aspirin intolerance, the importance of aspirin in cardiovascular disease, and the management of aspirin intolerance in both acute coronary syndrome and stable coronary artery disease. Our review includes a multidisciplinary approach from the internist, allergist/immunologist, and cardiologist when evaluating this important patient population.

KW - Acute coronary syndrome

KW - Aspirin intolerance

KW - Coronary artery disease

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JO - Cardiology and Therapy

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Coronary Artery Disease and Aspirin Intolerance: Background and Insights on Current Management

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