COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort

Garrett R. Roll; Robert A. Bray; Matthew Cooper; Todd N. Eagar; Howard M. Gebel; Gayle M. Vranic; Kelley M.K. Hitchman; Julie Houp; Malek Kamoun; John Killian; Jim Kim; Vineeta Kumar; Matthew Levine; Brendan P. Lovasik; Tyler Lunow-Luke; Ronald F. Parsons; Vikram Pattanayak; Daniel Ranch; Anushi Shah; Peter G. Stock; Olga A. Timofeeva; Jennifer Trofe-Clark; Chelsey Wongjirad; Heidi Yeh; Stephanie Yi; Raja Rajalingam

doi:10.1016/j.humimm.2023.02.005

COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort

Garrett R. Roll, Robert A. Bray, Matthew Cooper, Todd N. Eagar, Howard M. Gebel, Gayle M. Vranic, Kelley M.K. Hitchman, Julie Houp, Malek Kamoun, John Killian, Jim Kim, Vineeta Kumar, Matthew Levine, Brendan P. Lovasik, Tyler Lunow-Luke, Ronald F. Parsons, Vikram Pattanayak, Daniel Ranch, Anushi Shah, Peter G. StockOlga A. Timofeeva, Jennifer Trofe-Clark, Chelsey Wongjirad, Heidi Yeh, Stephanie Yi, Raja Rajalingam

Research output: Contribution to journal › Article › peer-review

Abstract

Although rare, infection and vaccination can result in antibodies to human leukocyte antigens (HLA). We analyzed the effect of SARS-CoV-2 infection or vaccination on HLA antibodies in waitlisted renal transplant candidates. Specificities were collected and adjudicated if the calculated panel reactive antibodies (cPRA) changed after exposure. Of 409 patients, 285 (69.7 %) had an initial cPRA of 0 %, and 56 (13.7 %) had an initial cPRA > 80 %. The cPRA changed in 26 patients (6.4 %), 16 (3.9 %) increased, and 10 (2.4 %) decreased. Based on cPRA adjudication, cPRA differences generally resulted from a small number of specificities with subtle fluctuations around the borderline of the participating centers’ cutoff for unacceptable antigen listing. All five COVID recovered patients with an increased cPRA were female (p = 0.02). In summary, exposure to this virus or vaccine does not increase HLA antibody specificities and their MFI in approximately 99 % of cases and 97 % of sensitized patients. These results have implications for virtual crossmatching at the time of organ offer after SARS-CoV-2 infection or vaccination, and these events of unclear clinical significance should not influence vaccination programs.

Original language	English (US)
Pages (from-to)	278-285
Number of pages	8
Journal	Human Immunology
Volume	84
Issue number	4
DOIs	https://doi.org/10.1016/j.humimm.2023.02.005
State	Published - Apr 2023

Keywords

COVID-19 vaccination
Kidney transplantation
Organ allocation
SARS-CoV-2 infection
Virtual crossmatch
Humans
Vaccination
Antibodies
Male
Isoantibodies
Kidney Transplantation/methods
COVID-19
SARS-CoV-2
Female
Histocompatibility Testing/methods
Tissue Donors
HLA Antigens

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.humimm.2023.02.005

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Roll, G. R., Bray, R. A., Cooper, M., Eagar, T. N., Gebel, H. M., Vranic, G. M., Hitchman, K. M. K., Houp, J., Kamoun, M., Killian, J., Kim, J., Kumar, V., Levine, M., Lovasik, B. P., Lunow-Luke, T., Parsons, R. F., Pattanayak, V., Ranch, D., Shah, A., ... Rajalingam, R. (2023). COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort. Human Immunology, 84(4), 278-285. https://doi.org/10.1016/j.humimm.2023.02.005

Roll, GR, Bray, RA, Cooper, M, Eagar, TN, Gebel, HM, Vranic, GM, Hitchman, KMK, Houp, J, Kamoun, M, Killian, J, Kim, J, Kumar, V, Levine, M, Lovasik, BP, Lunow-Luke, T, Parsons, RF, Pattanayak, V, Ranch, D, Shah, A, Stock, PG, Timofeeva, OA, Trofe-Clark, J, Wongjirad, C, Yeh, H, Yi, S & Rajalingam, R 2023, 'COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort', Human Immunology, vol. 84, no. 4, pp. 278-285. https://doi.org/10.1016/j.humimm.2023.02.005

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title = "COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort",

abstract = "Although rare, infection and vaccination can result in antibodies to human leukocyte antigens (HLA). We analyzed the effect of SARS-CoV-2 infection or vaccination on HLA antibodies in waitlisted renal transplant candidates. Specificities were collected and adjudicated if the calculated panel reactive antibodies (cPRA) changed after exposure. Of 409 patients, 285 (69.7 %) had an initial cPRA of 0 %, and 56 (13.7 %) had an initial cPRA > 80 %. The cPRA changed in 26 patients (6.4 %), 16 (3.9 %) increased, and 10 (2.4 %) decreased. Based on cPRA adjudication, cPRA differences generally resulted from a small number of specificities with subtle fluctuations around the borderline of the participating centers{\textquoteright} cutoff for unacceptable antigen listing. All five COVID recovered patients with an increased cPRA were female (p = 0.02). In summary, exposure to this virus or vaccine does not increase HLA antibody specificities and their MFI in approximately 99 % of cases and 97 % of sensitized patients. These results have implications for virtual crossmatching at the time of organ offer after SARS-CoV-2 infection or vaccination, and these events of unclear clinical significance should not influence vaccination programs.",

keywords = "COVID-19 vaccination, Kidney transplantation, Organ allocation, SARS-CoV-2 infection, Virtual crossmatch, Humans, Vaccination, Antibodies, Male, Isoantibodies, Kidney Transplantation/methods, COVID-19, SARS-CoV-2, Female, Histocompatibility Testing/methods, Tissue Donors, HLA Antigens",

author = "Roll, {Garrett R.} and Bray, {Robert A.} and Matthew Cooper and Eagar, {Todd N.} and Gebel, {Howard M.} and Vranic, {Gayle M.} and Hitchman, {Kelley M.K.} and Julie Houp and Malek Kamoun and John Killian and Jim Kim and Vineeta Kumar and Matthew Levine and Lovasik, {Brendan P.} and Tyler Lunow-Luke and Parsons, {Ronald F.} and Vikram Pattanayak and Daniel Ranch and Anushi Shah and Stock, {Peter G.} and Timofeeva, {Olga A.} and Jennifer Trofe-Clark and Chelsey Wongjirad and Heidi Yeh and Stephanie Yi and Raja Rajalingam",

note = "Copyright {\textcopyright} 2023. Published by Elsevier Inc.",

year = "2023",

month = apr,

doi = "10.1016/j.humimm.2023.02.005",

language = "English (US)",

volume = "84",

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T1 - COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort

AU - Roll, Garrett R.

AU - Bray, Robert A.

AU - Cooper, Matthew

AU - Eagar, Todd N.

AU - Gebel, Howard M.

AU - Vranic, Gayle M.

AU - Hitchman, Kelley M.K.

AU - Houp, Julie

AU - Kamoun, Malek

AU - Killian, John

AU - Kim, Jim

AU - Kumar, Vineeta

AU - Levine, Matthew

AU - Lovasik, Brendan P.

AU - Lunow-Luke, Tyler

AU - Parsons, Ronald F.

AU - Pattanayak, Vikram

AU - Ranch, Daniel

AU - Shah, Anushi

AU - Stock, Peter G.

AU - Timofeeva, Olga A.

AU - Trofe-Clark, Jennifer

AU - Wongjirad, Chelsey

AU - Yeh, Heidi

AU - Yi, Stephanie

AU - Rajalingam, Raja

PY - 2023/4

Y1 - 2023/4

N2 - Although rare, infection and vaccination can result in antibodies to human leukocyte antigens (HLA). We analyzed the effect of SARS-CoV-2 infection or vaccination on HLA antibodies in waitlisted renal transplant candidates. Specificities were collected and adjudicated if the calculated panel reactive antibodies (cPRA) changed after exposure. Of 409 patients, 285 (69.7 %) had an initial cPRA of 0 %, and 56 (13.7 %) had an initial cPRA > 80 %. The cPRA changed in 26 patients (6.4 %), 16 (3.9 %) increased, and 10 (2.4 %) decreased. Based on cPRA adjudication, cPRA differences generally resulted from a small number of specificities with subtle fluctuations around the borderline of the participating centers’ cutoff for unacceptable antigen listing. All five COVID recovered patients with an increased cPRA were female (p = 0.02). In summary, exposure to this virus or vaccine does not increase HLA antibody specificities and their MFI in approximately 99 % of cases and 97 % of sensitized patients. These results have implications for virtual crossmatching at the time of organ offer after SARS-CoV-2 infection or vaccination, and these events of unclear clinical significance should not influence vaccination programs.

AB - Although rare, infection and vaccination can result in antibodies to human leukocyte antigens (HLA). We analyzed the effect of SARS-CoV-2 infection or vaccination on HLA antibodies in waitlisted renal transplant candidates. Specificities were collected and adjudicated if the calculated panel reactive antibodies (cPRA) changed after exposure. Of 409 patients, 285 (69.7 %) had an initial cPRA of 0 %, and 56 (13.7 %) had an initial cPRA > 80 %. The cPRA changed in 26 patients (6.4 %), 16 (3.9 %) increased, and 10 (2.4 %) decreased. Based on cPRA adjudication, cPRA differences generally resulted from a small number of specificities with subtle fluctuations around the borderline of the participating centers’ cutoff for unacceptable antigen listing. All five COVID recovered patients with an increased cPRA were female (p = 0.02). In summary, exposure to this virus or vaccine does not increase HLA antibody specificities and their MFI in approximately 99 % of cases and 97 % of sensitized patients. These results have implications for virtual crossmatching at the time of organ offer after SARS-CoV-2 infection or vaccination, and these events of unclear clinical significance should not influence vaccination programs.

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KW - Kidney transplantation

KW - Organ allocation

KW - SARS-CoV-2 infection

KW - Virtual crossmatch

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KW - Antibodies

KW - Male

KW - Isoantibodies

KW - Kidney Transplantation/methods

KW - COVID-19

KW - SARS-CoV-2

KW - Female

KW - Histocompatibility Testing/methods

KW - Tissue Donors

KW - HLA Antigens

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ER -

COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort

Abstract

Keywords

ASJC Scopus subject areas

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