TY - JOUR
T1 - Cytotoxic drug-induced lung disease
AU - Sostman, Henry Dirk
AU - Matthay, Richard A.
AU - Putman, Charles E.
PY - 1977/1/1
Y1 - 1977/1/1
N2 - Cytotoxic drugs, principally bleomycin, methotrexate and busulfan, have been associated with pulmonary toxicity. Cytotoxic drug-induced lung disease may be difficult to establish with certainty because other causes of pulmonary disease are frequently present. We discuss the clinical, roentgenographic and histologic effects of the administration of bleomycin, methotrexate, busulfan and other cytotoxic agents on the lungs and suggest that these agents may also cause pulmonary malignancies. We note the importance of careful patient monitoring and withdrawal of a demonstrated offending agent.
AB - Cytotoxic drugs, principally bleomycin, methotrexate and busulfan, have been associated with pulmonary toxicity. Cytotoxic drug-induced lung disease may be difficult to establish with certainty because other causes of pulmonary disease are frequently present. We discuss the clinical, roentgenographic and histologic effects of the administration of bleomycin, methotrexate, busulfan and other cytotoxic agents on the lungs and suggest that these agents may also cause pulmonary malignancies. We note the importance of careful patient monitoring and withdrawal of a demonstrated offending agent.
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U2 - 10.1016/0002-9343(77)90424-7
DO - 10.1016/0002-9343(77)90424-7
M3 - Review article
C2 - 66869
AN - SCOPUS:0017582775
SN - 0002-9343
VL - 62
SP - 608
EP - 615
JO - The American journal of medicine
JF - The American journal of medicine
IS - 4
ER -