Designed and Evolved Nucleic Acid Nanotechnology: Contrast and Complementarity

Tulsi Ram Damase; Peter B Allen

doi:10.1021/acs.bioconjchem.8b00810

Designed and Evolved Nucleic Acid Nanotechnology: Contrast and Complementarity

Tulsi Ram Damase, Peter B Allen

Houston Methodist

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In this review, we explore progress on DNA aptamers (evolved DNA), DNA circuits (designed DNA), and the newest projects that integrate both. Designed DNA nanotechnology includes static nanostructures, dynamic nanodevices, and reaction networks (sometimes called DNA circuits). DNA circuits are dynamic DNA reactions that perform computations and sequence-specific amplification. Directed evolution can be used to produce DNA that can recognize specific targets. Aptamers are evolved nucleic acids; they are produced artificially with an in vitro selection process. DNA aptamers are molecular recognition elements made of single-stranded DNA (ssDNA) with the potential to interact with proteins, small molecules, viruses, and even cells. Designed molecular structures can incorporate aptamers for applications with immediate practical impact.

Original language	English (US)
Pages (from-to)	2-12
Number of pages	11
Journal	Bioconjugate chemistry
Volume	30
Issue number	1
DOIs	https://doi.org/10.1021/acs.bioconjchem.8b00810
State	Published - Jan 16 2019

Access to Document

10.1021/acs.bioconjchem.8b00810

Cite this

@article{301cceed6f4941d5a8a2102a1142ae4c,

title = "Designed and Evolved Nucleic Acid Nanotechnology: Contrast and Complementarity",

abstract = "In this review, we explore progress on DNA aptamers (evolved DNA), DNA circuits (designed DNA), and the newest projects that integrate both. Designed DNA nanotechnology includes static nanostructures, dynamic nanodevices, and reaction networks (sometimes called DNA circuits). DNA circuits are dynamic DNA reactions that perform computations and sequence-specific amplification. Directed evolution can be used to produce DNA that can recognize specific targets. Aptamers are evolved nucleic acids; they are produced artificially with an in vitro selection process. DNA aptamers are molecular recognition elements made of single-stranded DNA (ssDNA) with the potential to interact with proteins, small molecules, viruses, and even cells. Designed molecular structures can incorporate aptamers for applications with immediate practical impact.",

author = "Damase, {Tulsi Ram} and Allen, {Peter B}",

year = "2019",

month = jan,

day = "16",

doi = "10.1021/acs.bioconjchem.8b00810",

language = "English (US)",

volume = "30",

pages = "2--12",

journal = "Bioconjugate chemistry",

issn = "1043-1802",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Designed and Evolved Nucleic Acid Nanotechnology

T2 - Contrast and Complementarity

AU - Damase, Tulsi Ram

AU - Allen, Peter B

PY - 2019/1/16

Y1 - 2019/1/16

N2 - In this review, we explore progress on DNA aptamers (evolved DNA), DNA circuits (designed DNA), and the newest projects that integrate both. Designed DNA nanotechnology includes static nanostructures, dynamic nanodevices, and reaction networks (sometimes called DNA circuits). DNA circuits are dynamic DNA reactions that perform computations and sequence-specific amplification. Directed evolution can be used to produce DNA that can recognize specific targets. Aptamers are evolved nucleic acids; they are produced artificially with an in vitro selection process. DNA aptamers are molecular recognition elements made of single-stranded DNA (ssDNA) with the potential to interact with proteins, small molecules, viruses, and even cells. Designed molecular structures can incorporate aptamers for applications with immediate practical impact.

AB - In this review, we explore progress on DNA aptamers (evolved DNA), DNA circuits (designed DNA), and the newest projects that integrate both. Designed DNA nanotechnology includes static nanostructures, dynamic nanodevices, and reaction networks (sometimes called DNA circuits). DNA circuits are dynamic DNA reactions that perform computations and sequence-specific amplification. Directed evolution can be used to produce DNA that can recognize specific targets. Aptamers are evolved nucleic acids; they are produced artificially with an in vitro selection process. DNA aptamers are molecular recognition elements made of single-stranded DNA (ssDNA) with the potential to interact with proteins, small molecules, viruses, and even cells. Designed molecular structures can incorporate aptamers for applications with immediate practical impact.

U2 - 10.1021/acs.bioconjchem.8b00810

DO - 10.1021/acs.bioconjchem.8b00810

M3 - Article

C2 - 30561987

SN - 1043-1802

VL - 30

SP - 2

EP - 12

JO - Bioconjugate chemistry

JF - Bioconjugate chemistry

IS - 1

ER -

Designed and Evolved Nucleic Acid Nanotechnology: Contrast and Complementarity

Abstract

Access to Document

Fingerprint

Cite this