Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus

Esteban C. Nannini; Martin E. Stryjewski; Kavindra V. Singh; Tom H. Rude; G. Ralph Corey; Vance G. Fowler; Barbara E. Murray

doi:10.1128/AAC.01325-09

Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus

Esteban C. Nannini, Martin E. Stryjewski, Kavindra V. Singh, Tom H. Rude, G. Ralph Corey, Vance G. Fowler, Barbara E. Murray

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known β-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime. Ceftobiprole showed the lowest MICs at a high inoculum but with a slight increase for Bla-positive versus Bla-negative strains. Since a potential therapeutic effect associated with a cephalosporin inoculum effect has been described, further studies are warranted.

Original language	English (US)
Pages (from-to)	2206-2208
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	54
Issue number	5
DOIs	https://doi.org/10.1128/AAC.01325-09
State	Published - May 2010

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus",

abstract = "Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known β-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime. Ceftobiprole showed the lowest MICs at a high inoculum but with a slight increase for Bla-positive versus Bla-negative strains. Since a potential therapeutic effect associated with a cephalosporin inoculum effect has been described, further studies are warranted.",

author = "Nannini, {Esteban C.} and Stryjewski, {Martin E.} and Singh, {Kavindra V.} and Rude, {Tom H.} and {Ralph Corey}, G. and Fowler, {Vance G.} and Murray, {Barbara E.}",

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AU - Nannini, Esteban C.

AU - Stryjewski, Martin E.

AU - Singh, Kavindra V.

AU - Rude, Tom H.

AU - Ralph Corey, G.

AU - Fowler, Vance G.

AU - Murray, Barbara E.

PY - 2010/5

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AB - Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known β-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (especially types B and C), and no inoculum effects for ceftriaxone and cefuroxime. Ceftobiprole showed the lowest MICs at a high inoculum but with a slight increase for Bla-positive versus Bla-negative strains. Since a potential therapeutic effect associated with a cephalosporin inoculum effect has been described, further studies are warranted.

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Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus

Abstract

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