TY - JOUR
T1 - Developmental toxicity screening in zebrafish
AU - Mccollum, Catherine W.
AU - Ducharme, Nicole A.
AU - Bondesson, Maria
AU - Gustafsson, Jan-Ake
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Given the ever-increasing toxic exposure ubiquitously present in our environment as well as emerging evidence that these exposures are hazardous to human health, the current rodent-based regulations are proving inadequate. In the process of overhauling risk assessment methodology, a nonrodent test organism, the zebrafish, is emerging as tractable for medium- and high-throughput assessments, which may help to accelerate the restructuring of standards. Zebrafish have high developmental similarity to mammals in most aspects of embryo development, including early embryonic processes, and on cardiovascular, somite, muscular, skeletal, and neuronal systems. Here, we briefly describe the development of these systems and then chronicle the toxic impacts assessed following chemical exposure. We also compare the available data in zebrafish toxicity assays with two databases containing mammalian toxicity data. Finally, we identify gaps in our collective knowledge that are ripe for future studies.
AB - Given the ever-increasing toxic exposure ubiquitously present in our environment as well as emerging evidence that these exposures are hazardous to human health, the current rodent-based regulations are proving inadequate. In the process of overhauling risk assessment methodology, a nonrodent test organism, the zebrafish, is emerging as tractable for medium- and high-throughput assessments, which may help to accelerate the restructuring of standards. Zebrafish have high developmental similarity to mammals in most aspects of embryo development, including early embryonic processes, and on cardiovascular, somite, muscular, skeletal, and neuronal systems. Here, we briefly describe the development of these systems and then chronicle the toxic impacts assessed following chemical exposure. We also compare the available data in zebrafish toxicity assays with two databases containing mammalian toxicity data. Finally, we identify gaps in our collective knowledge that are ripe for future studies.
KW - Development
KW - High-throughput screening
KW - Toxicity
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=79958799645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958799645&partnerID=8YFLogxK
U2 - 10.1002/bdrc.20210
DO - 10.1002/bdrc.20210
M3 - Review article
C2 - 21671351
AN - SCOPUS:79958799645
SN - 1542-975X
VL - 93
SP - 67
EP - 114
JO - Birth Defects Research Part C - Embryo Today: Reviews
JF - Birth Defects Research Part C - Embryo Today: Reviews
IS - 2
ER -