Direct thrombin inhibitors

Rajeev Garg; Neal Kleiman; Eli Lev

doi:10.3109/9780203091494-25

Direct thrombin inhibitors

Rajeev Garg, Neal Kleiman, Eli Lev

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Role of thrombin in arterial thrombosis Thrombin (factor IIa) is a serine protease that is activated at the final step of the blood coagulation cascade and converts fibrinogen to fibrin. Thrombin has multiple roles - it is the most potent known platelet agonist, it is primarily responsible for thrombus propagation through the soluble clotting cascade, and it is also responsible for both positive and negative feedback within the coagulation cascade.

Original language	English (US)
Title of host publication	Clinical Guide to the Use of Antithrombotic Drugs in Coronary Artery Disease
Publisher	CRC Press
Pages	135-143
Number of pages	9
ISBN (Electronic)	9780203091494
ISBN (Print)	9781841846392
DOIs	https://doi.org/10.3109/9780203091494-25
State	Published - Jan 1 2008

ASJC Scopus subject areas

Medicine(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.3109/9780203091494-25

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Direct thrombin inhibitors

Abstract

ASJC Scopus subject areas

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