DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity

Yan Zhao; Linjie Guo; Shuting Cao; Mo Xie; Hongzhen Peng; Jiang Li; Shihua Luo; Lan Ma; Lihua Wang

doi:10.1039/d2cc05763h

DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity

Yan Zhao, Linjie Guo, Shuting Cao, Mo Xie, Hongzhen Peng, Jiang Li, Shihua Luo, Lan Ma, Lihua Wang

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We devise a class of amphiphilic drug complexes by programming hydrophobic drug patterns (HDPs) on DNA frameworks. We investigate the effect of HDPs on cellular uptake efficiency and drug potency. We achieve enhanced cytotoxicity against tumor cells by using an asymmetric HDP.

Original language	English (US)
Pages (from-to)	306-309
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	3
DOIs	https://doi.org/10.1039/d2cc05763h
State	Published - Nov 24 2022

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d2cc05763h

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title = "DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity",

abstract = "We devise a class of amphiphilic drug complexes by programming hydrophobic drug patterns (HDPs) on DNA frameworks. We investigate the effect of HDPs on cellular uptake efficiency and drug potency. We achieve enhanced cytotoxicity against tumor cells by using an asymmetric HDP.",

author = "Yan Zhao and Linjie Guo and Shuting Cao and Mo Xie and Hongzhen Peng and Jiang Li and Shihua Luo and Lan Ma and Lihua Wang",

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T1 - DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity

AU - Zhao, Yan

AU - Guo, Linjie

AU - Cao, Shuting

AU - Xie, Mo

AU - Peng, Hongzhen

AU - Li, Jiang

AU - Luo, Shihua

AU - Ma, Lan

AU - Wang, Lihua

PY - 2022/11/24

Y1 - 2022/11/24

N2 - We devise a class of amphiphilic drug complexes by programming hydrophobic drug patterns (HDPs) on DNA frameworks. We investigate the effect of HDPs on cellular uptake efficiency and drug potency. We achieve enhanced cytotoxicity against tumor cells by using an asymmetric HDP.

AB - We devise a class of amphiphilic drug complexes by programming hydrophobic drug patterns (HDPs) on DNA frameworks. We investigate the effect of HDPs on cellular uptake efficiency and drug potency. We achieve enhanced cytotoxicity against tumor cells by using an asymmetric HDP.

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U2 - 10.1039/d2cc05763h

DO - 10.1039/d2cc05763h

M3 - Article

C2 - 36507912

AN - SCOPUS:85144469142

SN - 1359-7345

VL - 59

SP - 306

EP - 309

JO - Chemical Communications

JF - Chemical Communications

IS - 3

ER -

DNA framework carriers with asymmetric hydrophobic drug patterns for enhanced cellular cytotoxicity

Abstract

ASJC Scopus subject areas

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