TY - JOUR
T1 - Early-Onset Micromorphological Changes of Neuronal Fiber Bundles During Radiotherapy
AU - Liu, Jin
AU - Wang, Wenjuan
AU - Zhou, Yanfei
AU - Gan, Chen
AU - Wang, Tengfei
AU - Hu, Zongtao
AU - Lou, Jianjun
AU - Wang, Hongzhi
AU - Yang, Li Zhuang
AU - Wong, Stephen T.C.
AU - Li, Hai
N1 - Funding Information:
The authors thank Ms. Chen Qi for her assistance in image data acquisition and Dr. Rebecca Danforth for proofreading the manuscript. This work was supported by the Key R&D Program of Anhui Province (201904a07020104), the Natural Science Fund of Anhui Province (2008085MC69), the General scientific research project of Anhui Provincial Health Commission (AHWJ2021b150), the Natural Science Fund of Hefei City (2021033), Collaborative Innovation Program of Hefei Science Center, CAS (2020HSC‐CIP001, 2021HSC‐CIP013), Anhui Province Key Laboratory of Medical Physics and Technology (LMPT201904), as well as John S Dunn Research Foundation and TT and WF Chao Foundation (S.T.C.W.).
Funding Information:
The authors thank Ms. Chen Qi for her assistance in image data acquisition and Dr. Rebecca Danforth for proofreading the manuscript. This work was supported by the Key R&D Program of Anhui Province (201904a07020104), the Natural Science Fund of Anhui Province (2008085MC69), the General scientific research project of Anhui Provincial Health Commission (AHWJ2021b150), the Natural Science Fund of Hefei City (2021033), Collaborative Innovation Program of Hefei Science Center, CAS (2020HSC-CIP001, 2021HSC-CIP013), Anhui Province Key Laboratory of Medical Physics and Technology (LMPT201904), as well as John S Dunn Research Foundation and TT and WF Chao Foundation (S.T.C.W.).
Publisher Copyright:
© 2021 International Society for Magnetic Resonance in Medicine.
PY - 2022/7
Y1 - 2022/7
N2 - BACKGROUND: Patients receiving cranial radiation face the risk of delayed brain dysfunction. However, an early medical imaging marker is not available until irreversible morphological changes emerge.PURPOSE: To explore the micromorphological white matter changes during the radiotherapy session by utilizing an along-tract analysis framework.STUDY TYPE: Prospective.POPULATION: Eighteen nasopharyngeal carcinoma (two female) patients receiving cranial radiation.FIELD STRENGTH/SEQUENCE: 3.0 T; Diffusion tensor imaging (DTI) and T1- and T2-weighted images (T1W, T2W); computed tomography (CT).ASSESSMENT: Patients received three DTI imaging scans during the radiotherapy (RT), namely the baseline scan (1-2 days before RT began), the middle scan (the middle of the RT session), and the end scan (1-2 days after RT ended). Twelve fibers were segmented after whole-brain tractography. Then, the fractional anisotropy (FA) values and the cumulative radiation dose received for each fiber streamline were resampled and projected into their center fiber.STATISTICAL TESTS: The contrast among the three scans (P1: middle scan-baseline scan; P2: end scan-middle scan; P3: end scan-baseline scan) were compared using the linear mixed model for each of the 12 center fibers. Then, a dose-responsiveness relationship was performed using Pearson correlation. P < 0.05 was considered statistically significant.RESULTS: Six of the 12 center fibers showed significant changes of FA values during the RT but with heterogeneous patterns. The significant changes along a specific center fiber were associated with their cumulative dose received (Genu: P1 r = -0.6182, P2 r = -0.5907; Splenium: P1 r = 0.4055, P = 0.1063, P2 r = 0.6742; right uncinate fasciculus: P1 r = -0.3865, P2 r = -0.4912, P = 0.0533; right corticospinal tract: P1 r = 0.4273, P = 0.1122, P2 r = -0.6885).DATA CONCLUSION: The along-tract analysis might provide sensitive measures on the early-onset micromorphological changes.LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY: Stage 3.
AB - BACKGROUND: Patients receiving cranial radiation face the risk of delayed brain dysfunction. However, an early medical imaging marker is not available until irreversible morphological changes emerge.PURPOSE: To explore the micromorphological white matter changes during the radiotherapy session by utilizing an along-tract analysis framework.STUDY TYPE: Prospective.POPULATION: Eighteen nasopharyngeal carcinoma (two female) patients receiving cranial radiation.FIELD STRENGTH/SEQUENCE: 3.0 T; Diffusion tensor imaging (DTI) and T1- and T2-weighted images (T1W, T2W); computed tomography (CT).ASSESSMENT: Patients received three DTI imaging scans during the radiotherapy (RT), namely the baseline scan (1-2 days before RT began), the middle scan (the middle of the RT session), and the end scan (1-2 days after RT ended). Twelve fibers were segmented after whole-brain tractography. Then, the fractional anisotropy (FA) values and the cumulative radiation dose received for each fiber streamline were resampled and projected into their center fiber.STATISTICAL TESTS: The contrast among the three scans (P1: middle scan-baseline scan; P2: end scan-middle scan; P3: end scan-baseline scan) were compared using the linear mixed model for each of the 12 center fibers. Then, a dose-responsiveness relationship was performed using Pearson correlation. P < 0.05 was considered statistically significant.RESULTS: Six of the 12 center fibers showed significant changes of FA values during the RT but with heterogeneous patterns. The significant changes along a specific center fiber were associated with their cumulative dose received (Genu: P1 r = -0.6182, P2 r = -0.5907; Splenium: P1 r = 0.4055, P = 0.1063, P2 r = 0.6742; right uncinate fasciculus: P1 r = -0.3865, P2 r = -0.4912, P = 0.0533; right corticospinal tract: P1 r = 0.4273, P = 0.1122, P2 r = -0.6885).DATA CONCLUSION: The along-tract analysis might provide sensitive measures on the early-onset micromorphological changes.LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY: Stage 3.
KW - along-tract analysis
KW - diffusion tensor imaging
KW - imaging biomarkers
KW - nasopharyngeal carcinoma
KW - radiation-induced brain injury
KW - radiotherapy
KW - Prospective Studies
KW - Humans
KW - Nasopharyngeal Neoplasms/diagnostic imaging
KW - Brain/diagnostic imaging
KW - White Matter/pathology
KW - Anisotropy
KW - Female
KW - Diffusion Tensor Imaging/methods
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U2 - 10.1002/jmri.28018
DO - 10.1002/jmri.28018
M3 - Article
C2 - 34854521
AN - SCOPUS:85120372510
SN - 1053-1807
VL - 56
SP - 210
EP - 218
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 1
ER -