Early secretory antigenic target-6 of Mycobacterium tuberculosis: Enigmatic factor in pathogen-host interactions

Ramesh Chandra Rai; Ved Prakash Dwivedi; Samit Chatterjee; Durbaka Vijaya Raghava Prasad; Gobardhan Das

doi:10.1016/j.micinf.2012.07.019

Early secretory antigenic target-6 of Mycobacterium tuberculosis: Enigmatic factor in pathogen-host interactions

Ramesh Chandra Rai, Ved Prakash Dwivedi, Samit Chatterjee, Durbaka Vijaya Raghava Prasad, Gobardhan Das

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

T helper (Th) 1 and 17 cells play important roles in host protective responses against tuberculosis. Early Secretory Antigenic Target 6; a Region of Difference 1 (RD1) encoded protein, mounts Th17-responses in the lung. Therefore, lack of RD-1 region makes Bacillus Calmette-Guérin (BCG) less vaccine efficacious than parent strains.

Original language	English (US)
Pages (from-to)	1220-1226
Number of pages	7
Journal	Microbes and Infection
Volume	14
Issue number	13
DOIs	https://doi.org/10.1016/j.micinf.2012.07.019
State	Published - Nov 2012

Keywords

BCG
CFP10
ESAT6
Innate/adaptive immunity
Mycobacterium tuberculosis
RD-1

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/j.micinf.2012.07.019

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title = "Early secretory antigenic target-6 of Mycobacterium tuberculosis: Enigmatic factor in pathogen-host interactions",

abstract = "T helper (Th) 1 and 17 cells play important roles in host protective responses against tuberculosis. Early Secretory Antigenic Target 6; a Region of Difference 1 (RD1) encoded protein, mounts Th17-responses in the lung. Therefore, lack of RD-1 region makes Bacillus Calmette-Gu{\'e}rin (BCG) less vaccine efficacious than parent strains.",

keywords = "BCG, CFP10, ESAT6, Innate/adaptive immunity, Mycobacterium tuberculosis, RD-1",

author = "{Chandra Rai}, Ramesh and Dwivedi, {Ved Prakash} and Samit Chatterjee and {Raghava Prasad}, {Durbaka Vijaya} and Gobardhan Das",

note = "Funding Information: This work was supported by grants from The Wellcome-DBT India Alliance and the Department of Biotechnology, Government of India ; and by the International Center for Genetic Engineering and Biotechnology, New Delhi , India.",

year = "2012",

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doi = "10.1016/j.micinf.2012.07.019",

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TY - JOUR

T1 - Early secretory antigenic target-6 of Mycobacterium tuberculosis

T2 - Enigmatic factor in pathogen-host interactions

AU - Chandra Rai, Ramesh

AU - Dwivedi, Ved Prakash

AU - Chatterjee, Samit

AU - Raghava Prasad, Durbaka Vijaya

AU - Das, Gobardhan

N1 - Funding Information: This work was supported by grants from The Wellcome-DBT India Alliance and the Department of Biotechnology, Government of India ; and by the International Center for Genetic Engineering and Biotechnology, New Delhi , India.

PY - 2012/11

Y1 - 2012/11

N2 - T helper (Th) 1 and 17 cells play important roles in host protective responses against tuberculosis. Early Secretory Antigenic Target 6; a Region of Difference 1 (RD1) encoded protein, mounts Th17-responses in the lung. Therefore, lack of RD-1 region makes Bacillus Calmette-Guérin (BCG) less vaccine efficacious than parent strains.

AB - T helper (Th) 1 and 17 cells play important roles in host protective responses against tuberculosis. Early Secretory Antigenic Target 6; a Region of Difference 1 (RD1) encoded protein, mounts Th17-responses in the lung. Therefore, lack of RD-1 region makes Bacillus Calmette-Guérin (BCG) less vaccine efficacious than parent strains.

KW - BCG

KW - CFP10

KW - ESAT6

KW - Innate/adaptive immunity

KW - Mycobacterium tuberculosis

KW - RD-1

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DO - 10.1016/j.micinf.2012.07.019

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SN - 1286-4579

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ER -

Early secretory antigenic target-6 of Mycobacterium tuberculosis: Enigmatic factor in pathogen-host interactions

Abstract

Keywords

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