Abstract
The effect of cellular elements in the blood on peripheral vascular function in mice was evaluated using the pressure-velocity relationships in the iliac arteries of 5 wild type (WT) and 3 polycythemic (MH) mice. Pressure was obtained using a fluid filled catheter in the left iliac artery and blood velocity was measured in the right iliac artery using a 20 MHz pulsed Doppler probe. The proximal aorta was then occluded for one minute to allow flow velocity to decay to zero. The pressure-velocity relationship in the diastolic phase was determined before and after aortic occlusion. In both groups the pressure-velocity relationship was almost linear and the slopes were similar. However, the extrapolated zero-velocity intercept was significantly higher for the MH than WT mice before (55.4±4.0 vs. 36.2±4.1 mmHg, p<0.01) and after occlusion (50.7±5.5 vs. 23.8±3.1 mmHg, p<0.01). Hematocrits were 41%±3 in WT and 59%±3 in MH mice. These data show that cellular elements in the blood alter the pressure-velocity relationships in peripheral vessels of mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3720-3722 |
| Number of pages | 3 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 26 V |
| State | Published - Dec 1 2004 |
| Event | Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States Duration: Sep 1 2004 → Sep 5 2004 |
Keywords
- Doppler ultrasound
- Mouse iliac artery
- Peripheral vascular resistance
- Polycythemia
- Pulsatility index
- Resistance index
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics