TY - JOUR
T1 - Effectiveness of B Vitamin Supplementation Following Bariatric Surgery
T2 - Rapid Increases of Serum Vitamin B12
AU - Moore, Carolyn E.
AU - Sherman, Vadim
N1 - Funding Information:
This project was funded in part by a Chancellor’s Research Fellowship from Texas Woman’s University. Multivitamin supplements were donated by Celebrate®.
Publisher Copyright:
© 2014, Springer Science+Business Media New York.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Background: Few prospective studies have compared changes of nutrient intake while assessing effectiveness of thiamin, vitamin B12, and folate supplementation to prevent B vitamin deficiencies immediately following Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Therefore, we determined the response to 3 months supplementation on maintaining blood B vitamin concentrations. Methods: Women undergoing RYGB (n = 11) and SG (n = 11) consumed bariatric vitamin supplements (12 mg thiamin, 350 μg vitamin B12, 800 μg folic acid) daily for 3 months. Height, weight, body mass index, and blood vitamin concentrations were measured preoperatively and at 3 months. Wilcoxon signed-rank analyses compared body weight parameters, laboratory indices, and nutrient intake at baseline and 3 months. Results: Supplementation for 3 months maintained blood thiamin, increased serum folate from 13.1 ± 5.4 to 16.3 ± 6.0 nmol/L (P = 0.049), and increased serum vitamin B12 concentrations from 498 ± 150 to 736 ± 340 pg/mL (P = 0.005). Dietary intake of thiamin and folate decreased in the combined surgical groups, while dietary intake of B12 was maintained. Bariatric B vitamin supplements provided multiple intakes of the Recommended Dietary Allowances (1090 % thiamin, 14,583 % vitamin B12, 200 % folate). Conclusions: Although energy intake decreased 64 %, B vitamin supplementation for 3 months resulted in a 48 % increase of serum vitamin B12, a modest increase of serum folate, and no reduction of blood thiamin concentrations. Long-term effects of the rapid rise of serum B12 levels attributed to the high content of supplements warrant further investigation.
AB - Background: Few prospective studies have compared changes of nutrient intake while assessing effectiveness of thiamin, vitamin B12, and folate supplementation to prevent B vitamin deficiencies immediately following Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Therefore, we determined the response to 3 months supplementation on maintaining blood B vitamin concentrations. Methods: Women undergoing RYGB (n = 11) and SG (n = 11) consumed bariatric vitamin supplements (12 mg thiamin, 350 μg vitamin B12, 800 μg folic acid) daily for 3 months. Height, weight, body mass index, and blood vitamin concentrations were measured preoperatively and at 3 months. Wilcoxon signed-rank analyses compared body weight parameters, laboratory indices, and nutrient intake at baseline and 3 months. Results: Supplementation for 3 months maintained blood thiamin, increased serum folate from 13.1 ± 5.4 to 16.3 ± 6.0 nmol/L (P = 0.049), and increased serum vitamin B12 concentrations from 498 ± 150 to 736 ± 340 pg/mL (P = 0.005). Dietary intake of thiamin and folate decreased in the combined surgical groups, while dietary intake of B12 was maintained. Bariatric B vitamin supplements provided multiple intakes of the Recommended Dietary Allowances (1090 % thiamin, 14,583 % vitamin B12, 200 % folate). Conclusions: Although energy intake decreased 64 %, B vitamin supplementation for 3 months resulted in a 48 % increase of serum vitamin B12, a modest increase of serum folate, and no reduction of blood thiamin concentrations. Long-term effects of the rapid rise of serum B12 levels attributed to the high content of supplements warrant further investigation.
KW - Bariatric surgery
KW - Folate
KW - Thiamin
KW - Vitamin B
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U2 - 10.1007/s11695-014-1441-5
DO - 10.1007/s11695-014-1441-5
M3 - Article
C2 - 25270794
AN - SCOPUS:84925854260
SN - 0960-8923
VL - 25
SP - 694
EP - 699
JO - Obesity Surgery
JF - Obesity Surgery
IS - 4
ER -