Efficacy of ceftobiprole medocaril against Enterococcus faecalis in a murine urinary tract infection model

Kavindra V. Singh; Barbara E. Murray

doi:10.1128/AAC.06102-11

Efficacy of ceftobiprole medocaril against Enterococcus faecalis in a murine urinary tract infection model

Kavindra V. Singh, Barbara E. Murray

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8 Scopus citations

Abstract

We evaluated ceftobiprole against the well-characterized Enterococcus faecalis strain OG1RF (with and without the β-lactamase [Bla] plasmid pBEM10) in a murine urinary tract infection (UTI) model. Ceftobiprole was equally effective for Bla⁺ and Bla^- OG1 strains, while ampicillin was moderately to markedly (depending on the inoculum) less effective against Bla⁺ than Bla^- OG1 strains. These data illustrate an in vivo effect on ampicillin of Bla production by E. faecalis and the stability and efficacy of ceftobiprole in experimental UTI.

Original language	English (US)
Pages (from-to)	3457-3460
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	56
Issue number	6
DOIs	https://doi.org/10.1128/AAC.06102-11
State	Published - Jun 2012

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "We evaluated ceftobiprole against the well-characterized Enterococcus faecalis strain OG1RF (with and without the β-lactamase [Bla] plasmid pBEM10) in a murine urinary tract infection (UTI) model. Ceftobiprole was equally effective for Bla+ and Bla- OG1 strains, while ampicillin was moderately to markedly (depending on the inoculum) less effective against Bla+ than Bla- OG1 strains. These data illustrate an in vivo effect on ampicillin of Bla production by E. faecalis and the stability and efficacy of ceftobiprole in experimental UTI.",

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Efficacy of ceftobiprole medocaril against Enterococcus faecalis in a murine urinary tract infection model

Abstract

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