TY - JOUR
T1 - Efficacy of deoxycholate amphotericin B and unilamellar liposomal amphotericin B in prophylaxis of experimental Aspergillus fumigatus endocarditis
AU - Mylonakis, Eleftherios
AU - Chalevelakis, George
AU - Saroglou, George
AU - Danias, Peter
AU - Argyropoulou, Athina D.
AU - Paniara, Olga
AU - Raptis, Sotirios A.
PY - 1997
Y1 - 1997
N2 - Objective: To evaluate and compare in vivo the protective efficacy of unilamellar liposomal amphotericin B (L-AmB) with that of deoxycholate amphotericin B (D-AmB) in experimental endocarditis. Material and Methods: In the rabbit model of experimental Aspergillus fumigatus endocarditis, two doses of each antifungal agent (1.5 mg/kg each) were administered intravenously at 4 hours and at 30 minutes before challenge with an inoculum of A. fumigatus. Three days later, the animals were sacrificed, and the aortic vegetations were analyzed. Results: All 19 animals that did not receive chemoprophylaxis acquired endocarditis. In contrast, endocarditis developed in 2 of 10 animals pretreated with D-AmB (P<0.01) and 3 of 8 animals pretreated with L-AmB (P<0.01). Both D-AmB and L-AmB prevented the development of endocarditis due to A. fumigatus and decreased the concentration of fungi in the aortic vegetations by more than 1 log10. Conclusion: In the rabbit experimental model of Aspergillus endocarditis, D- AmB and L-AmB were equally effective in reducing the incidence of the infection and the tissue burden of fungi.
AB - Objective: To evaluate and compare in vivo the protective efficacy of unilamellar liposomal amphotericin B (L-AmB) with that of deoxycholate amphotericin B (D-AmB) in experimental endocarditis. Material and Methods: In the rabbit model of experimental Aspergillus fumigatus endocarditis, two doses of each antifungal agent (1.5 mg/kg each) were administered intravenously at 4 hours and at 30 minutes before challenge with an inoculum of A. fumigatus. Three days later, the animals were sacrificed, and the aortic vegetations were analyzed. Results: All 19 animals that did not receive chemoprophylaxis acquired endocarditis. In contrast, endocarditis developed in 2 of 10 animals pretreated with D-AmB (P<0.01) and 3 of 8 animals pretreated with L-AmB (P<0.01). Both D-AmB and L-AmB prevented the development of endocarditis due to A. fumigatus and decreased the concentration of fungi in the aortic vegetations by more than 1 log10. Conclusion: In the rabbit experimental model of Aspergillus endocarditis, D- AmB and L-AmB were equally effective in reducing the incidence of the infection and the tissue burden of fungi.
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U2 - 10.4065/72.11.1022
DO - 10.4065/72.11.1022
M3 - Article
AN - SCOPUS:0030727212
SN - 0025-6196
VL - 72
SP - 1022
EP - 1027
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 11
ER -