TY - JOUR
T1 - Efficacy of omadacycline against multidrug-resistant enterococcus faecium Strains in a Mouse Peritonitis Model
AU - Singh, Kavindra V.
AU - Arias, Cesar A.
AU - Murray, Barbara E.
N1 - Funding Information:
This work was supported by Paratek Pharmaceuticals, Inc., in the form of an investigator-initiated grant to the University of Texas Health Science Center, McGovern Medical School (B.E.M., PI). C.A.A. was partially supported by NIH/NIAID grants R01 AI134637, R21 AI143229, K24 AI121296, P01-AI152999-01, R01-AI148342-01, T32AI141349, and UM1AI104681, a UTHealth Presidential Award, and a University of Texas System STARS Award. B.E.M. and K.V.S. were supported in part by R21 AI133289-01A1, R21 AI143229, and R01 AI121400 from NIAID. We thank Karen Jacques-Palaz for technical assistance.
Publisher Copyright:
Copyright © 2021 American Society for Microbiology. All Rights Reserved.
PY - 2021/8/17
Y1 - 2021/8/17
N2 - Omadacycline (OMC) showed better
in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Van
r, Amp
r, DAP-nonsusceptible, linezolid-resistant,
cfr(B)
+ Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable
in vitro and
in vivo efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.
AB - Omadacycline (OMC) showed better
in vitro potency than daptomycin (DAP) or vancomycin (VAN) against Van
r, Amp
r, DAP-nonsusceptible, linezolid-resistant,
cfr(B)
+ Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparable
in vitro and
in vivo efficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.
KW - E. faecium
KW - Mouse peritonitis
KW - Omadacycline
KW - Microbial Sensitivity Tests
KW - Enterococcus faecium
KW - Animals
KW - Tetracyclines/pharmacology
KW - Peritonitis/drug therapy
KW - Mice
KW - Gram-Positive Bacterial Infections/drug therapy
KW - Anti-Bacterial Agents/pharmacology
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U2 - 10.1128/AAC.00709-21
DO - 10.1128/AAC.00709-21
M3 - Article
C2 - 34125596
AN - SCOPUS:85112853305
SN - 0066-4804
VL - 65
SP - e0070921
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 9
M1 - 00709
ER -