Ejection fraction and ventricular volumes on rubidium positron emission tomography: Validation against cardiovascular magnetic resonance

Yushui Han, Ahmed Ibrahim Ahmed, Jean Michel Saad, Fares Alahdab, Mahmoud S. Al Rifai, Venkatesh L. Murthy, Mouaz H. Al-Mallah

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

BACKGROUND: Cardiovascular magnetic resonance (CMR) is the non-invasive gold standard for non-invasively determining left ventricular volumes (LVVs) and ejection fraction (EF). We aimed to assess the accuracy of LVV and left ventricular ejection fraction measured by positron emission tomography (PET) as compared to CMR.

METHODS: Patients who underwent both PET and CMR within 1 year were identified from prospective institutional registries. Analysis was performed to evaluate the agreement between the raw and body-surface-area-normalized left ventricular volume (LVV) and EF derived from PET vs. those derived from CMR.

RESULTS: The study population consisted of 669 patients (mean age 62 ± 13 years, 65% male). The median (interquartile range [IQR]) duration between CMR and PET imaging was 36 (7-118) days. The median (IQR) EF values were 52% (38-63%) on CMR and 53% (37-65%) on PET (mean difference: 0.53% ± 9.1, P = 0.129) with a strong correlation (Spearman rho = 0.84, P < 0.001; Intraclass Correlation Coefficient 0.84, 95% confidence interval [CI]: 0.82-0.86, P < 0.001; Lin's concordance correlation coefficient was 0.844, 95% CI: 0.822 to 0.865). Results were similar with LVV, normalized LVV/EF, and in subgroups of patients with reduced EF, coronary artery disease scar, and LV hypertrophy as well as in patients with defibrillators. However, PET tended to underestimate LVV compared to CMR.

CONCLUSION: Our analysis showed a strong correlation of EF and LVV by PET against a reference standard of CMR, whereas PET significantly underestimated LVV, but not EF, compared to CMR.

Original languageEnglish (US)
Article number101810
Pages (from-to)101810
JournalJournal of Nuclear Cardiology
Volume32
DOIs
StatePublished - Feb 2024

Keywords

  • LV ejection fraction
  • LV end diastolic volume
  • LV end systolic volume
  • MRI
  • Multimodality
  • PET
  • Rubidium
  • Prospective Studies
  • Ventricular Function, Left
  • Magnetic Resonance Spectroscopy
  • Humans
  • Middle Aged
  • Male
  • Tomography, X-Ray Computed
  • Positron-Emission Tomography
  • Stroke Volume
  • Female
  • Aged
  • Heart Ventricles/diagnostic imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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