TY - JOUR
T1 - Ejection fraction and ventricular volumes on rubidium positron emission tomography
T2 - Validation against cardiovascular magnetic resonance
AU - Han, Yushui
AU - Ahmed, Ahmed Ibrahim
AU - Saad, Jean Michel
AU - Alahdab, Fares
AU - Al Rifai, Mahmoud S.
AU - Murthy, Venkatesh L.
AU - Al-Mallah, Mouaz H.
N1 - Copyright © 2024 American Society of Nuclear Cardiology. Published by Elsevier Inc. All rights reserved.
PY - 2024/2
Y1 - 2024/2
N2 - BACKGROUND: Cardiovascular magnetic resonance (CMR) is the non-invasive gold standard for non-invasively determining left ventricular volumes (LVVs) and ejection fraction (EF). We aimed to assess the accuracy of LVV and left ventricular ejection fraction measured by positron emission tomography (PET) as compared to CMR.METHODS: Patients who underwent both PET and CMR within 1 year were identified from prospective institutional registries. Analysis was performed to evaluate the agreement between the raw and body-surface-area-normalized left ventricular volume (LVV) and EF derived from PET vs. those derived from CMR.RESULTS: The study population consisted of 669 patients (mean age 62 ± 13 years, 65% male). The median (interquartile range [IQR]) duration between CMR and PET imaging was 36 (7-118) days. The median (IQR) EF values were 52% (38-63%) on CMR and 53% (37-65%) on PET (mean difference: 0.53% ± 9.1, P = 0.129) with a strong correlation (Spearman rho = 0.84, P < 0.001; Intraclass Correlation Coefficient 0.84, 95% confidence interval [CI]: 0.82-0.86, P < 0.001; Lin's concordance correlation coefficient was 0.844, 95% CI: 0.822 to 0.865). Results were similar with LVV, normalized LVV/EF, and in subgroups of patients with reduced EF, coronary artery disease scar, and LV hypertrophy as well as in patients with defibrillators. However, PET tended to underestimate LVV compared to CMR.CONCLUSION: Our analysis showed a strong correlation of EF and LVV by PET against a reference standard of CMR, whereas PET significantly underestimated LVV, but not EF, compared to CMR.
AB - BACKGROUND: Cardiovascular magnetic resonance (CMR) is the non-invasive gold standard for non-invasively determining left ventricular volumes (LVVs) and ejection fraction (EF). We aimed to assess the accuracy of LVV and left ventricular ejection fraction measured by positron emission tomography (PET) as compared to CMR.METHODS: Patients who underwent both PET and CMR within 1 year were identified from prospective institutional registries. Analysis was performed to evaluate the agreement between the raw and body-surface-area-normalized left ventricular volume (LVV) and EF derived from PET vs. those derived from CMR.RESULTS: The study population consisted of 669 patients (mean age 62 ± 13 years, 65% male). The median (interquartile range [IQR]) duration between CMR and PET imaging was 36 (7-118) days. The median (IQR) EF values were 52% (38-63%) on CMR and 53% (37-65%) on PET (mean difference: 0.53% ± 9.1, P = 0.129) with a strong correlation (Spearman rho = 0.84, P < 0.001; Intraclass Correlation Coefficient 0.84, 95% confidence interval [CI]: 0.82-0.86, P < 0.001; Lin's concordance correlation coefficient was 0.844, 95% CI: 0.822 to 0.865). Results were similar with LVV, normalized LVV/EF, and in subgroups of patients with reduced EF, coronary artery disease scar, and LV hypertrophy as well as in patients with defibrillators. However, PET tended to underestimate LVV compared to CMR.CONCLUSION: Our analysis showed a strong correlation of EF and LVV by PET against a reference standard of CMR, whereas PET significantly underestimated LVV, but not EF, compared to CMR.
KW - LV ejection fraction
KW - LV end diastolic volume
KW - LV end systolic volume
KW - MRI
KW - Multimodality
KW - PET
KW - Rubidium
KW - Prospective Studies
KW - Ventricular Function, Left
KW - Magnetic Resonance Spectroscopy
KW - Humans
KW - Middle Aged
KW - Male
KW - Tomography, X-Ray Computed
KW - Positron-Emission Tomography
KW - Stroke Volume
KW - Female
KW - Aged
KW - Heart Ventricles/diagnostic imaging
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U2 - 10.1016/j.nuclcard.2024.101810
DO - 10.1016/j.nuclcard.2024.101810
M3 - Article
C2 - 38286326
AN - SCOPUS:85186749246
SN - 1071-3581
VL - 32
SP - 101810
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
M1 - 101810
ER -