Abstract
Electrical stimulation of the cerebellar fastigial nucleus (FN) in rat (1 h) reduces, by 50%, the infarction produced by occlusion of the middle cerebral artery (MCAO). We investigated whether salvage was associated with elevations in regional cerebral blood flow (rCBF) and/or reductions of regional cerebral glucose utilization (rCGU) in the retrievable zone (RZ). rCGU and rCBF were measured autoradiographically 1 h after MCAO. MCAO reduced rCBF to <15% in the irretrievable zone (IZ) and ~50% in the RZ (P < 0.01 for each) while FN stimulation alone globally elevated rCBF by ~60% (P < 0.01). rCGU was not changed. After MCAO, FN stimulation failed to increase the reduced rCBF but elevated rCGU globally (to ~30%). Reductions of focal ischemic infarctions by stimulating FN cannot be attributed to changes in rCBF and or rCGU.
Original language | English (US) |
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Pages (from-to) | 181-184 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 210 |
Issue number | 3 |
DOIs | |
State | Published - Jun 7 1996 |
Keywords
- Autoradiography
- Electrical stimulation
- Fastigial nucleus
- Local ischemia
- Middle cerebral artery
- Regional cerebral blood flow
- Regional cerebral glucose utilization
ASJC Scopus subject areas
- Neuroscience(all)