Engineering multicellular living systems—a Keystone Symposia report

Jennifer Cable; Paola Arlotta; Kevin Kit Parker; Alex J. Hughes; Katharine Goodwin; Christine L. Mummery; Roger D. Kamm; Sandra J. Engle; Danilo A. Tagle; Sylvia F. Boj; Alice E. Stanton; Yoshihiro Morishita; Melissa L. Kemp; Dennis A. Norfleet; Elebeoba E. May; Aric Lu; Rashid Bashir; Adam W. Feinberg; Sarah M. Hull; Anjelica L. Gonzalez; Michael R. Blatchley; Núria Montserrat Pulido; Ryuji Morizane; Todd C. McDevitt; Deepak Mishra; Adriana Mulero-Russe

doi:10.1111/nyas.14896

Engineering multicellular living systems—a Keystone Symposia report

Jennifer Cable, Paola Arlotta, Kevin Kit Parker, Alex J. Hughes, Katharine Goodwin, Christine L. Mummery, Roger D. Kamm, Sandra J. Engle, Danilo A. Tagle, Sylvia F. Boj, Alice E. Stanton, Yoshihiro Morishita, Melissa L. Kemp, Dennis A. Norfleet, Elebeoba E. May, Aric Lu, Rashid Bashir, Adam W. Feinberg, Sarah M. Hull, Anjelica L. GonzalezMichael R. Blatchley, Núria Montserrat Pulido, Ryuji Morizane, Todd C. McDevitt, Deepak Mishra, Adriana Mulero-Russe

Houston Methodist

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The ability to engineer complex multicellular systems has enormous potential to inform our understanding of biological processes and disease and alter the drug development process. Engineering living systems to emulate natural processes or to incorporate new functions relies on a detailed understanding of the biochemical, mechanical, and other cues between cells and between cells and their environment that result in the coordinated action of multicellular systems. On April 3–6, 2022, experts in the field met at the Keystone symposium “Engineering Multicellular Living Systems” to discuss recent advances in understanding how cells cooperate within a multicellular system, as well as recent efforts to engineer systems like organ-on-a-chip models, biological robots, and organoids. Given the similarities and common themes, this meeting was held in conjunction with the symposium “Organoids as Tools for Fundamental Discovery and Translation”.

Original language	English (US)
Pages (from-to)	183-195
Number of pages	13
Journal	Annals of the New York Academy of Sciences
Volume	1518
Issue number	1
DOIs	https://doi.org/10.1111/nyas.14896
State	Published - Dec 2022

Keywords

computational
engineered living
engineered organs
multicellular
systems

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/nyas.14896

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Cable, J., Arlotta, P., Parker, K. K., Hughes, A. J., Goodwin, K., Mummery, C. L., Kamm, R. D., Engle, S. J., Tagle, D. A., Boj, S. F., Stanton, A. E., Morishita, Y., Kemp, M. L., Norfleet, D. A., May, E. E., Lu, A., Bashir, R., Feinberg, A. W., Hull, S. M., ... Mulero-Russe, A. (2022). Engineering multicellular living systems—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1518(1), 183-195. https://doi.org/10.1111/nyas.14896

Cable, J, Arlotta, P, Parker, KK, Hughes, AJ, Goodwin, K, Mummery, CL, Kamm, RD, Engle, SJ, Tagle, DA, Boj, SF, Stanton, AE, Morishita, Y, Kemp, ML, Norfleet, DA, May, EE, Lu, A, Bashir, R, Feinberg, AW, Hull, SM, Gonzalez, AL, Blatchley, MR, Montserrat Pulido, N, Morizane, R, McDevitt, TC, Mishra, D & Mulero-Russe, A 2022, 'Engineering multicellular living systems—a Keystone Symposia report', Annals of the New York Academy of Sciences, vol. 1518, no. 1, pp. 183-195. https://doi.org/10.1111/nyas.14896

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abstract = "The ability to engineer complex multicellular systems has enormous potential to inform our understanding of biological processes and disease and alter the drug development process. Engineering living systems to emulate natural processes or to incorporate new functions relies on a detailed understanding of the biochemical, mechanical, and other cues between cells and between cells and their environment that result in the coordinated action of multicellular systems. On April 3–6, 2022, experts in the field met at the Keystone symposium “Engineering Multicellular Living Systems” to discuss recent advances in understanding how cells cooperate within a multicellular system, as well as recent efforts to engineer systems like organ-on-a-chip models, biological robots, and organoids. Given the similarities and common themes, this meeting was held in conjunction with the symposium “Organoids as Tools for Fundamental Discovery and Translation”.",

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AU - Lu, Aric

AU - Bashir, Rashid

AU - Feinberg, Adam W.

AU - Hull, Sarah M.

AU - Gonzalez, Anjelica L.

AU - Blatchley, Michael R.

AU - Montserrat Pulido, Núria

AU - Morizane, Ryuji

AU - McDevitt, Todd C.

AU - Mishra, Deepak

AU - Mulero-Russe, Adriana

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Engineering multicellular living systems—a Keystone Symposia report

Abstract

Keywords

ASJC Scopus subject areas

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