Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2

Pei Pei Yang; Xin Wei Ye; Mei Qin Liu; Jin Xuan Yang; Xiao Li Feng; Yi Jing Li; Kuo Zhang; Hong Wen Liang; Yu Yi; Lei Wang; Yi Xuan Liu; Xing Lou Yang; Zheng Li Shi; Li Qiang Feng; Ling Chen; Yintong Xue; Qiang Pan-Hammarström; Hao Wang; Yuliang Zhao

doi:10.1002/adhm.202300673

Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2

Pei Pei Yang, Xin Wei Ye, Mei Qin Liu, Jin Xuan Yang, Xiao Li Feng, Yi Jing Li, Kuo Zhang, Hong Wen Liang, Yu Yi, Lei Wang, Yi Xuan Liu, Xing Lou Yang, Zheng Li Shi, Li Qiang Feng, Ling Chen, Yintong Xue, Qiang Pan-Hammarström, Hao Wang, Yuliang Zhao

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.

Original language	English (US)
Article number	2300673
Journal	Advanced Healthcare Materials
Volume	12
Issue number	24
DOIs	https://doi.org/10.1002/adhm.202300673
State	Published - Sep 25 2023

Keywords

anti-virals
biomimetics
nanofibers
peptides
self-assembly

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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10.1002/adhm.202300673

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Yang, P. P., Ye, X. W., Liu, M. Q., Yang, J. X., Feng, X. L., Li, Y. J., Zhang, K., Liang, H. W., Yi, Y., Wang, L., Liu, Y. X., Yang, X. L., Shi, Z. L., Feng, L. Q., Chen, L., Xue, Y., Pan-Hammarström, Q., Wang, H., & Zhao, Y. (2023). Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2. Advanced Healthcare Materials, 12(24), Article 2300673. https://doi.org/10.1002/adhm.202300673

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title = "Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2",

abstract = "The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.",

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author = "Yang, {Pei Pei} and Ye, {Xin Wei} and Liu, {Mei Qin} and Yang, {Jin Xuan} and Feng, {Xiao Li} and Li, {Yi Jing} and Kuo Zhang and Liang, {Hong Wen} and Yu Yi and Lei Wang and Liu, {Yi Xuan} and Yang, {Xing Lou} and Shi, {Zheng Li} and Feng, {Li Qiang} and Ling Chen and Yintong Xue and Qiang Pan-Hammarstr{\"o}m and Hao Wang and Yuliang Zhao",

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year = "2023",

month = sep,

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doi = "10.1002/adhm.202300673",

language = "English (US)",

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AU - Yang, Pei Pei

AU - Ye, Xin Wei

AU - Liu, Mei Qin

AU - Yang, Jin Xuan

AU - Feng, Xiao Li

AU - Li, Yi Jing

AU - Zhang, Kuo

AU - Liang, Hong Wen

AU - Yi, Yu

AU - Wang, Lei

AU - Liu, Yi Xuan

AU - Yang, Xing Lou

AU - Shi, Zheng Li

AU - Feng, Li Qiang

AU - Chen, Ling

AU - Xue, Yintong

AU - Pan-Hammarström, Qiang

AU - Wang, Hao

AU - Zhao, Yuliang

PY - 2023/9/25

Y1 - 2023/9/25

N2 - The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.

AB - The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.

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KW - self-assembly

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Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2

Abstract

Keywords

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