TY - JOUR
T1 - Enterococcus faecium Clade Competition in the Presence of β-Lactam Antibiotics in a Mouse GI Tract Colonization Model
AU - Singh, Kavindra V.
AU - Murray, Barbara
AU - Montealegre, Maria Camila
N1 - Funding Information:
This work was supported by the National Institutes of Health from the Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (grant R21 AI103260-01 to B.E.M.). B.E.M. and K.V.S. were in part supported by R21AI133289-01A1 from NIAID. We thank Karen Jacques-Palaz for technical assistance.
Publisher Copyright:
© 2022 American Society for Microbiology.
PY - 2022/10/18
Y1 - 2022/10/18
N2 - Previously, we showed that Enterococcus faecium clade B strains outcompeted health care-associated clade A1 strains in murine gastrointestinal colonization. Here, parenterally administered piperacillin-tazobactam and ceftriaxone significantly promoted colonization by clade A1 over clade B strains except that ceftriaxone, at the dose used, did not favor the least β-lactam-resistant A1 strain. The advantage that β-lactam administration gives to more highly ampicillin-resistant E. faecium over ampicillin-susceptible strains mirrors what occurs in hospitalized patients administered these antibiotics.
AB - Previously, we showed that Enterococcus faecium clade B strains outcompeted health care-associated clade A1 strains in murine gastrointestinal colonization. Here, parenterally administered piperacillin-tazobactam and ceftriaxone significantly promoted colonization by clade A1 over clade B strains except that ceftriaxone, at the dose used, did not favor the least β-lactam-resistant A1 strain. The advantage that β-lactam administration gives to more highly ampicillin-resistant E. faecium over ampicillin-susceptible strains mirrors what occurs in hospitalized patients administered these antibiotics.
KW - E. faecium
KW - ampicillin resistant
KW - ceftriaxone
KW - mouse GI colonization
KW - piperacillin-tazobactam
KW - beta-Lactams/pharmacology
KW - Gastrointestinal Tract
KW - Monobactams
KW - Anti-Bacterial Agents/pharmacology
KW - Ceftriaxone/pharmacology
KW - Enterococcus faecium
KW - Animals
KW - Ampicillin/pharmacology
KW - Mice
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U2 - 10.1128/aac.00903-22
DO - 10.1128/aac.00903-22
M3 - Article
C2 - 36255277
SN - 0066-4804
VL - 66
SP - 1
EP - 5
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 11
M1 - https://doi.org/10.1128/aac.00903-22
ER -