TY - JOUR
T1 - Eotaxin-1/CCL11 correlates with left superior temporal gyrus in bipolar disorder
T2 - A preliminary report suggesting accelerated brain aging
AU - Mohite, Satyajit
AU - Cordeiro, Thiago
AU - Tannous, Jonika
AU - Mwangi, Benson
AU - Selvaraj, Sudhakar
AU - Soares, Jair C.
AU - Sanches, Marsal
AU - Teixeira, Antonio L.
N1 - Copyright © 2020 Elsevier B.V. All rights reserved.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Background: Neuropsychiatric disorders have been linked to immune mechanisms. Altered peripheral levels of eotaxin-1/CCL11; a cytokine implicated in allergic reactions and aging process; have been reported in bipolar disorder (BD). Several brain areas, especially the temporal lobe, seem to display volume loss and accelerated aging in BD. This study aimed at exploring potential associations between eotaxins and brain volumes in patients with BD compared to controls. Methods: Twenty-two euthymic patients with BD and 22 controls were enrolled in this study. Serum levels of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26 were determined alongside brain volumes. Results: There were no differences in the levels of eotaxins between patients and controls. A negative correlation was found between eotaxin-1/CCL11 levels and left-hemisphere's superior-temporal volume only in BD patients, which persisted with covariate adjusted model. Conclusion: This study corroborates the emerging evidence of association between inflammation and brain volumes in BD. Our preliminary results also support the hypothesis of a possible role of eotaxin-1/CCL11 in accelerated brain aging in BD.
AB - Background: Neuropsychiatric disorders have been linked to immune mechanisms. Altered peripheral levels of eotaxin-1/CCL11; a cytokine implicated in allergic reactions and aging process; have been reported in bipolar disorder (BD). Several brain areas, especially the temporal lobe, seem to display volume loss and accelerated aging in BD. This study aimed at exploring potential associations between eotaxins and brain volumes in patients with BD compared to controls. Methods: Twenty-two euthymic patients with BD and 22 controls were enrolled in this study. Serum levels of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26 were determined alongside brain volumes. Results: There were no differences in the levels of eotaxins between patients and controls. A negative correlation was found between eotaxin-1/CCL11 levels and left-hemisphere's superior-temporal volume only in BD patients, which persisted with covariate adjusted model. Conclusion: This study corroborates the emerging evidence of association between inflammation and brain volumes in BD. Our preliminary results also support the hypothesis of a possible role of eotaxin-1/CCL11 in accelerated brain aging in BD.
KW - Accelerated aging
KW - Bipolar disorder
KW - CCL-11
KW - Eotaxin
KW - Superior-temporal volume
KW - Brain/diagnostic imaging
KW - Humans
KW - Aging
KW - Temporal Lobe/diagnostic imaging
KW - Bipolar Disorder/diagnostic imaging
KW - Chemokine CCL11/metabolism
UR - http://www.scopus.com/inward/record.url?scp=85085321024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85085321024&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2020.05.062
DO - 10.1016/j.jad.2020.05.062
M3 - Article
C2 - 32560958
AN - SCOPUS:85085321024
SN - 0165-0327
VL - 273
SP - 592
EP - 596
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -