TY - JOUR
T1 - ERβ
T2 - Recent understanding of estrogen signaling
AU - Sugiyama, Nobuhiro
AU - Barros, Rodrigo P.A.
AU - Warner, Margaret
AU - Gustafsson, Jan Åke
N1 - Funding Information:
This work was supported by a grant from the Swedish Cancer Fund. J-Å.G. is a consultant and shareholder of KaroBio AB.
PY - 2010/9
Y1 - 2010/9
N2 - The discovery of a second estrogen receptor, ERβ, and the finding that 5α-androstane-3β,17β-diol (3βAdiol) strongly binds to ERβ, have opened up a new aspect of estrogen signaling. Some of the major shifts in our understanding come from finding ERβ in tissues which do not express ERα but are estrogen-responsive; these were called sites of 'indirect estrogen action'. Two key sites that fall into this category are the brain and the prostate. Studies of ERβ in the past 10 years have led us to hypothesize that estrogen signaling depends on the balance between ERα and ERβ, and that inadequate predominance of one or the other isoform could lead to disease.
AB - The discovery of a second estrogen receptor, ERβ, and the finding that 5α-androstane-3β,17β-diol (3βAdiol) strongly binds to ERβ, have opened up a new aspect of estrogen signaling. Some of the major shifts in our understanding come from finding ERβ in tissues which do not express ERα but are estrogen-responsive; these were called sites of 'indirect estrogen action'. Two key sites that fall into this category are the brain and the prostate. Studies of ERβ in the past 10 years have led us to hypothesize that estrogen signaling depends on the balance between ERα and ERβ, and that inadequate predominance of one or the other isoform could lead to disease.
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U2 - 10.1016/j.tem.2010.05.001
DO - 10.1016/j.tem.2010.05.001
M3 - Review article
C2 - 20646931
AN - SCOPUS:77956185965
SN - 1043-2760
VL - 21
SP - 545
EP - 552
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 9
ER -