TY - JOUR
T1 - Estrogen receptors and the metabolic network
AU - Barros, Rodrigo P.A.
AU - Gustafsson, Jan Åke
N1 - Funding Information:
This work was supported by the Swedish Cancer Society, the Emerging Technology Fund of Texas, and the Robert A. Welch Foundation. The authors apologize for not citing all relevant articles due to reference limitations. J-Å.G. is a consultant of Karo Bio AB and Bionovo, Inc.
PY - 2011/9/7
Y1 - 2011/9/7
N2 - The metabolic syndrome has reached pandemic level worldwide, and evidence is that estradiol plays a key role in its development. The discovery of the second estrogen receptor, ERβ, in tissues previously not considered targets of estradiol was a breakthrough in endocrinology. In the present review, we discuss how the presence of ERβ and the previously described ERα in tissues involved in glucose and lipid homeostasis (brain, skeletal muscle, adipose tissue, pancreas, liver, and heart) may have important implications to risk factors associated with the metabolic syndrome. Imbalance of ERα/ERβ ratio in this "metabolic network" may lead to the metabolic syndrome.
AB - The metabolic syndrome has reached pandemic level worldwide, and evidence is that estradiol plays a key role in its development. The discovery of the second estrogen receptor, ERβ, in tissues previously not considered targets of estradiol was a breakthrough in endocrinology. In the present review, we discuss how the presence of ERβ and the previously described ERα in tissues involved in glucose and lipid homeostasis (brain, skeletal muscle, adipose tissue, pancreas, liver, and heart) may have important implications to risk factors associated with the metabolic syndrome. Imbalance of ERα/ERβ ratio in this "metabolic network" may lead to the metabolic syndrome.
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U2 - 10.1016/j.cmet.2011.08.005
DO - 10.1016/j.cmet.2011.08.005
M3 - Review article
C2 - 21907136
AN - SCOPUS:80052742071
SN - 1550-4131
VL - 14
SP - 289
EP - 299
JO - Cell Metabolism
JF - Cell Metabolism
IS - 3
ER -