@article{7dca197109d94300a9a0c4319c229318,
title = "Evolution of Cefiderocol Non-Susceptibility in Pseudomonas aeruginosa in a Patient Without Previous Exposure to the Antibiotic",
abstract = "We report the emergence of non-susceptibility to cefiderocol from a subpopulation of Pseudomonas aeruginosa recovered from a patient without history of cefiderocol exposure. Whole genome sequencing identified mutations in major iron transport pathways previously associated with cefiderocol uptake. Susceptibility testing should be performed before therapy with siderophore cephalosporins.",
keywords = "Pseudomonas aeruginosa, antibiotic resistance, cefiderocol",
author = "Streling, {Ana Paula} and {Al Obaidi}, {Mohanad M.} and Lainhart, {William D.} and Tirdad Zangeneh and Ayesha Khan and Dinh, {An Q.} and Blake Hanson and Arias, {Cesar A.} and Miller, {William R.}",
note = "Funding Information: This work was supported by the National Institutes of Health/National Institute of Allergy and Infectious Diseases NIH/NIAID grants R01 AI134637, R01 AI148342, K01AI148593-01, and K24 AI121296, UTHealth Presidential Award, and University of Texas System STARS Award to C. A. A. W. R. M. is supported by NIH/NIAID K08 AI135093. The funding agency had no role in experimental design, data collection, or interpretation of this work. Publisher Copyright: {\textcopyright} The Author(s) 2021.",
year = "2021",
month = dec,
day = "1",
doi = "10.1093/cid/ciaa1909",
language = "English (US)",
volume = "73",
pages = "E4472--E4474",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "11",
}