Abstract
Background/Aims: This study aimed to determine the clinical and neuroimaging correlates of the presence of neuropsychiatric symptoms in stroke patients with age-related confluent white matter hyperintensities (WMH). Methods: The Neuropsychiatric Inventory was utilized to detect the presence of 12 symptoms. Multivariate logistic regression models were used to identify clinical and neuroimaging correlates of the presence of symptoms. Results: Seventy-seven stroke patients (mean WMH volume: 39.5 cm3) were recruited. Thirty patients (39%) had ≥1 neuropsychiatric symptom. Poor executive function was associated with the presence of any symptoms and symptoms other than depression. More severe left frontal WMH was associated with depression. Conclusion: Executive dysfunction and left frontal WMH are correlated with neuropsychiatric symptoms in these patients.
Original language | English (US) |
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Pages (from-to) | 254-260 |
Number of pages | 7 |
Journal | Dementia and Geriatric Cognitive Disorders |
Volume | 30 |
Issue number | 3 |
DOIs | |
State | Published - Oct 2010 |
Keywords
- Depression
- Executive function
- Frontal lobe atrophy
- Neuropsychiatry
- Stroke
- White matter hyperintensities
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Cognitive Neuroscience