Experimental Cholesterol Granuloma

Thomas S. Main; Tadao Shimada; David J. Lim

doi:10.1001/archotol.1970.00770040514010

Experimental Cholesterol Granuloma

Thomas S. Main, Tadao Shimada, David J. Lim

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Abstract

Cholesterol granulomas were produced in the mastoid cavity of the squirrel monkey by obstructing the eustachian tube with silicone-rubber (Silastic) sponges. It was noted that these granulomas developed only in the mastoid cells, which is suggestive that isolation of hemorrhage in a small area without ventilation is an important factor in the genesis of cholesterol granulomas. Our experiment favors the concept that hemorrhage in mastoid air cells, possibly due to negative pressure, has a vital role in the pathogenesis of this disease.

Original language	English (US)
Pages (from-to)	356-359
Number of pages	4
Journal	Archives of Otolaryngology
Volume	91
Issue number	4
DOIs	https://doi.org/10.1001/archotol.1970.00770040514010
State	Published - Apr 1970

ASJC Scopus subject areas

Otorhinolaryngology

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10.1001/archotol.1970.00770040514010

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abstract = "Cholesterol granulomas were produced in the mastoid cavity of the squirrel monkey by obstructing the eustachian tube with silicone-rubber (Silastic) sponges. It was noted that these granulomas developed only in the mastoid cells, which is suggestive that isolation of hemorrhage in a small area without ventilation is an important factor in the genesis of cholesterol granulomas. Our experiment favors the concept that hemorrhage in mastoid air cells, possibly due to negative pressure, has a vital role in the pathogenesis of this disease.",

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AU - Shimada, Tadao

AU - Lim, David J.

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AB - Cholesterol granulomas were produced in the mastoid cavity of the squirrel monkey by obstructing the eustachian tube with silicone-rubber (Silastic) sponges. It was noted that these granulomas developed only in the mastoid cells, which is suggestive that isolation of hemorrhage in a small area without ventilation is an important factor in the genesis of cholesterol granulomas. Our experiment favors the concept that hemorrhage in mastoid air cells, possibly due to negative pressure, has a vital role in the pathogenesis of this disease.

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Experimental Cholesterol Granuloma

Abstract

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