Exploring the brain epitranscriptome: perspectives from the NSAS summit

Sung Min Lee; Bonsang Koo; Clément Carré; André Fischer; Chuan He; Ajeet Kumar; Kathy Liu; Kate D. Meyer; Guo Li Ming; Junmin Peng; Jean Yves Roignant; Erik Storkebaum; Shuying Sun; Davide De Pietri Tonelli; Yinsheng Wang; Yi Lan Weng; Luigi Pulvirenti; Yanhong Shi; Ki Jun Yoon; Hongjun Song

doi:10.3389/fnins.2023.1291446

Exploring the brain epitranscriptome: perspectives from the NSAS summit

Sung Min Lee, Bonsang Koo, Clément Carré, André Fischer, Chuan He, Ajeet Kumar, Kathy Liu, Kate D. Meyer, Guo Li Ming, Junmin Peng, Jean Yves Roignant, Erik Storkebaum, Shuying Sun, Davide De Pietri Tonelli, Yinsheng Wang, Yi Lan Weng, Luigi Pulvirenti, Yanhong Shi, Ki Jun Yoon, Hongjun Song

Research output: Contribution to journal › Article › peer-review

Abstract

Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. The inaugural NSAS Challenge Workshop on Brain Epitranscriptomics hosted in Crans-Montana, Switzerland in 2023 assembled a group of experts from the field, to discuss the current state of the field and provide novel translational perspectives. A summary of the discussions at the workshop is presented here to simulate broader engagement from the general neuroscience field.

Original language	English (US)
Article number	1291446
Journal	Frontiers in Neuroscience
Volume	17
DOIs	https://doi.org/10.3389/fnins.2023.1291446
State	Published - 2023

Keywords

RNA modifications
epitranscriptome
glioblastoma
neurodevelopment
neuroepitranscriptomics
neurogenesis

ASJC Scopus subject areas

Neuroscience(all)

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10.3389/fnins.2023.1291446

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Lee, S. M., Koo, B., Carré, C., Fischer, A., He, C., Kumar, A., Liu, K., Meyer, K. D., Ming, G. L., Peng, J., Roignant, J. Y., Storkebaum, E., Sun, S., De Pietri Tonelli, D., Wang, Y., Weng, Y. L., Pulvirenti, L., Shi, Y., Yoon, K. J., & Song, H. (2023). Exploring the brain epitranscriptome: perspectives from the NSAS summit. Frontiers in Neuroscience, 17, Article 1291446. https://doi.org/10.3389/fnins.2023.1291446

Lee, SM, Koo, B, Carré, C, Fischer, A, He, C, Kumar, A, Liu, K, Meyer, KD, Ming, GL, Peng, J, Roignant, JY, Storkebaum, E, Sun, S, De Pietri Tonelli, D, Wang, Y, Weng, YL, Pulvirenti, L, Shi, Y, Yoon, KJ & Song, H 2023, 'Exploring the brain epitranscriptome: perspectives from the NSAS summit', Frontiers in Neuroscience, vol. 17, 1291446. https://doi.org/10.3389/fnins.2023.1291446

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abstract = "Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. The inaugural NSAS Challenge Workshop on Brain Epitranscriptomics hosted in Crans-Montana, Switzerland in 2023 assembled a group of experts from the field, to discuss the current state of the field and provide novel translational perspectives. A summary of the discussions at the workshop is presented here to simulate broader engagement from the general neuroscience field.",

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author = "Lee, {Sung Min} and Bonsang Koo and Cl{\'e}ment Carr{\'e} and Andr{\'e} Fischer and Chuan He and Ajeet Kumar and Kathy Liu and Meyer, {Kate D.} and Ming, {Guo Li} and Junmin Peng and Roignant, {Jean Yves} and Erik Storkebaum and Shuying Sun and {De Pietri Tonelli}, Davide and Yinsheng Wang and Weng, {Yi Lan} and Luigi Pulvirenti and Yanhong Shi and Yoon, {Ki Jun} and Hongjun Song",

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AU - Sun, Shuying

AU - De Pietri Tonelli, Davide

AU - Wang, Yinsheng

AU - Weng, Yi Lan

AU - Pulvirenti, Luigi

AU - Shi, Yanhong

AU - Yoon, Ki Jun

AU - Song, Hongjun

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Exploring the brain epitranscriptome: perspectives from the NSAS summit

Abstract

Keywords

ASJC Scopus subject areas

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