@article{53a598773be0446787b91b47859dcf24,
title = "Factors Influencing Alzheimer{\textquoteright}s Disease Risk: Whether and How They are Related to the APOE Genotype",
abstract = "Alzheimer's disease (AD) is the most prevalent neurodegenerative disease featuring progressive cognitive impairment. Although the etiology of late-onset AD remains unclear, the close association of AD with apolipoprotein E (APOE), a gene that mainly regulates lipid metabolism, has been firmly established and may shed light on the exploration of AD pathogenesis and therapy. However, various confounding factors interfere with the APOE-related AD risk, raising questions about our comprehension of the clinical findings concerning APOE. In this review, we summarize the most debated factors interacting with the APOE genotype and AD pathogenesis, depict the extent to which these factors relate to APOE-dependent AD risk, and discuss the possible underlying mechanisms.",
keywords = "Aging, Alzheimer{\textquoteright}s disease, Apolipoprotein E, Diet, Ethnicity, Gender, Geographic factor, Apolipoproteins E/genetics, Neurodegenerative Diseases, Alzheimer Disease/genetics, Humans, Risk Factors, Genotype, Lipid Metabolism, Apolipoprotein E4/genetics",
author = "Rong Zhang and Xiaojiao Xu and Hang Yu and Xiaolan Xu and Manli Wang and Weidong Le",
note = "Funding Information: We thank Professor Hongmei Li from Department of Neuroscience, Mayo Clinic and Yingjun Zhao from Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University for their critical review of this manuscript. This work was supported by the Chengdu Science and Technology Bureau (2019-YF05-00655-SN), Key Project of the Medical Science Department, University of Electronic Science and Technology of China (ZYGX2020ZB035) and Guangdong Provincial Key R&D Program (2018B030337001). Funding Information: We thank Professor Hongmei Li from Department of Neuroscience, Mayo Clinic and Yingjun Zhao from Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University for their critical review of this manuscript. This work was supported by the Chengdu Science and Technology Bureau (2019-YF05-00655-SN), Key Project of the Medical Science Department, University of Electronic Science and Technology of China (ZYGX2020ZB035) and Guangdong Provincial Key R&D Program (2018B030337001). Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = jul,
doi = "10.1007/s12264-021-00814-5",
language = "English (US)",
volume = "38",
pages = "809--819",
journal = "Neuroscience Bulletin",
issn = "1673-7067",
publisher = "Science Press",
number = "7",
}